7. Low magnification
Patchy distribution of the foci
A bronchiole filled with
inflammatory cells in the center
of the focus
Detached epithelial cells
IMAGE OF PRACTICAL SECTION
RS② ---- Bronchopneumonia
8. High magnification
Large amount of
necrotic neutrophils
fill the bronchiole
lumen and adjacent
alveolar spaces.
The capillaries of
alveolar walls are
congestive.
RS② ---- Bronchopneumonia
9. US① acute diffuse proliferative
glomerulonephritis
The most characteristic change
occurs in glomeruli
Diffuse - nearly all glomeruli are
affected
Enlarged glomeruli with increased
cellularity
Proliferation and swelling of
endothelial and mesangial cells
Infiltration of inflammatory cells
10. Other changes in renal tubules
and interstitium
Protein casts or red cells casts
in the renal tubules
Mesenchymal renal hyperemia
and exudative lesions
Infiltration of some neutrophils
US① acute diffuse proliferative
glomerulonephritis
11. The lesions were characterized by
inflammatory infiltration in the
renal interstitium.
The cells infiltration is mainly
consisted of lymphocytes which
may aggregate and form
lymphocytic follicules.
US③ Chronic Pyelonephritis
12. Glomerulosclerosis may be
seen in some areas
"Colloid casts" are present in
the dilated tubules
US③ Chronic Pyelonephritis
14. DS② Chronic Gastric Ulceration
Microscopically,at low power, a ulcer can be seen.
15. DS② Chronic Gastric Ulceration
necrosis
granulation tissue
inflammatory exudate
Goblet cells
Thickened
vessel
proliferating
nerve fibers
Scar layer
Smooth musle
At medium power,
inflammatory infiltration
layer, necrotic layer,
granulation tissue ,scar
tissue on base of ulcer can
be seen.
Proliferating nerve fibers
and thickened vessels can
be also seen.
16. DS⑥ Gastric adenocarcinoma
Irregular gland formation
The malignancy invades the muscle wall
Mucus secreted by the tumor cells fills
the lumen
Cellular and nuclear pleomorphism with
abnormal spindle
17. DS⑧ subacute fulminant hepatitis
Destruction of classic liver nodules
Disorderly nodular regeneration of
hepatocytes with numerous fibrosis
Bile duct proliferation and cholestasis
Infiltrate of mononuclear inflammatory
cells
18. DS ④ portal cirrhosis
Regenerating liver nodules in varying
sizes separated by fibrous tissue bands
Hepatocytes in the nodules are arranged
turbulently, with absent or deviated
central vein
Bile duct proliferation and lymphocyte
infiltration in the fibrous septa
Fatty change and bile pigment can be
seen sometimes
19. DS⑤ hepatocellular carcinoma
The tumor cells are arranged in nests with
relatively clear borders
Dilated sinusoids
Cellular and nuclear pleomorphism
Infiltrate of lymphocyte in surrounding
stroma
Non-neoplastic, preserved hepatocytic
cords are compressed
20. GS① Hydatidiform Mole
The chorionic villi show hydropic
swelling----the central substance of
the villi is a loose, myxomatous,
edematous stroma.
The vessels of villi decrease or
disappear
proliferation of the chorionic
epithelium including
syncytiotrophoblast cells and
cytotrophoblast cells in different
degree
21. GS④ Invasive Mole
Microscopic view
Retained hydropic villi
penetrate the uterine wall
deeply.
The epithelium of the villi
is marked by hyperplastic
and atypical changes,
with proliferation of both
syncytiotrophoblast cells
and cytotrophoblast cells
22. GS② Choriocarcinoma of uterus
The tumor is composed
of obviously atypical
hyperplasia of
cytotrophoblasts and
syncytiotrophoblasts,
arranged in nests and
cords.
The tumor invades the
uterine wall.
syncytiotrophoblasts
cytotrophoblasts
myometrium
myometrium
syncytiotrophoblasts
23. GS② Choriocarcinoma of uterus
Choriocarcinoma shows clear
cytotrophoblastic cells with
central nuclei and light stained
cytoplasm and
syncytiotrophoblastic cells with
multiple dark nuclei embedded in
eosinophilic cytoplasm.
There are no stroma and vessels
in the tumor. Chorionic villi are
not formed, accompanying with
masses of hemorrhage
syncytiotrophoblasts
cytotrophoblasts
24. NP⑧ thyroid adenoma
At low magnification, the tumor is
demarcated from the surrounding normal
thyroid parenchyma by well-formed
capsule.
The constituent cells are arranged in
uniform follicles that contain colloid.
Regressive changes are usually present
in the tumor.
Areas of hemorrhage
25. ES② Graves disease
The follicle of thyroid are varial in size
with many small hyperplastic follicles
that the follicular epithelial cells are tall
and columnar with nuclei at the basis.
The colloid within follicular lumen is
pale with the scalloped appearance of
the edges.
Lymphocytes formed lymphoid
follicles.
26. MS① ----Osteosarcoma
Island of osteoid
(pink-staining) and
calcified osteoid
(dark-staining)
Anaplastic tumor
cells
Giant cells
osteoid
calcified
osteoid
27. MS① ----Osteosarcoma
Malignant cells---spindle
shaped and uniform or
quite pleomorphic, with
bizarre, hyperchromatic
nuclei and frequent
mitotic figures.
28. NS① ---Acute purulent meningitis
The vessels in the
subarachnoid space are
intensely congested.
Meninges contain an amount
of neutrophils and fibrin in
the subarachnoid space
Infection of the underlying
brain parenchyma is rare.
