Myasthenia Gravis - Pathophysiology, Cl. Features, DD

PATHOPHYSIOLOGY CLINICAL FEATURES AND DIFFERENTIAL DIAGNOSES Myasthenia gravis Dr JISHANTH M Prof Dr A Gowrishankar’s Unit Dept. of Internal Medicine

INTRODUCTION ,[object Object],[object Object],[object Object]

PATHOPHYSIOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Myasthenia Gravis ,[object Object],Antibodies Simplified Motor Endplates

PATHOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

THYMIC AND OTHER ASSOCIATED DISORDERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pathologic Features of the Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object]

CLINICAL FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object]

CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

OSSERMAN Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PROGRESSION OF DISEASE ,[object Object],[object Object],[object Object],[object Object]

REMISSIONS ,[object Object],[object Object],[object Object],[object Object]

BASIC PHYSICAL EXAMINATION ,[object Object],[object Object],[object Object]

CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bulbar Muscles

1. OCULAR MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

2. FACIAL MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object]

3. BULBAR MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

4. LIMB MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],Upper Extremities Deltoids Wrist extensors Finger extensors Triceps > Biceps Lower Extremities Hip flexors (most common) Quadriceps Hamstrings Foot dorsiflexors Plantar flexors

5. RESPIRATORY MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CO-EXISTING AUTOIMMUNE DISEASES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MYASTHENIC CRISIS ,[object Object],[object Object],[object Object],[object Object],[object Object]

NEUROLOGIC CONDITIONS MIMICKING MYASTHENIA GRAVIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

LAMBERT-EATON SYNDROME ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DRUGS PRECIPITATING MYASTHENIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Prognosis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Differential diagnoses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Myasthenia Gravis - Pathophysiology, Cl. Features, DD

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Myasthenia Gravis - Pathophysiology, Cl. Features, DD

Editor's Notes