e coli

1. Enteropathogenic
Escherichia Coli Infection
BY
SOWMIYA G
17PW24160
Dr.T.V.Rao MD

2. Bacteria
Gram
positive
Cocci Bacilli
Gram
negative
Cocci Rods

3. Enterobacteriaceae
 Commonly present in large intestine
 A complex family of organisms,
 Some are non pathogenic
 A few are highly Pathogenic.

4. Classification of Enterobacteriaceae
Enterobacteriaceae
Lactose fermenters
E. coli, Citrobacter,
Klebsiella, Enterobacter
Non-lactose fermenter
Salmonell, Shigella
Proteus, Yersinia

5. Escherichia coli
 Named by Escherichia
 It can Produce infections in
Humans and Animals
Detection of E.coli in water
indicates pollution and
contamination.

6. Classification
 Domain: Bacteria
 Kingdom: Bacteria
 Phylum: Proteobacteria
 Class: Gamma
Proteobacteria
 Order: Enterobacteriales
 Family: Enterobacteriaceae
 Genus: Escherichia
 Species: Escherichia coli (E.
coli)

7. E.coli
 Morphology Gram - ve Straight
rods,
 1-3 X 0.4 -0.7 microns,
 Appear in singles or in pairs,
 Motile by flagella.
 Very few strains non motile
 Not spore forming.

8. E.coli
Cultural characters
 Aerobic / Facultative Anaerobic
 Grows between 10 – 40 c optimal at 37 c
 Grown in simple medium

9. E.coli

10. Classification of E.coli
1.Enteropathogenic EPEC
2.Enterotoxigenic ETEC
3.Enteroinvasive EIEC
4.Enterohemorrhagic EHEC
5.Enteroaggresive EAEC

11. Toxins and E.coli
 E.coli produce Exotoxins
 Hemolysins, Enterotoxins causes
Diarrheas,
 Important toxins produces.
 Heat labile HL Heat stable HS
Vero toxins VT Like Shigella toxins

12. Toxins
 Enterotoxins – produced by enterotoxigenic
strains of E. coli (ETEC). Causes a
movement of water and ions from the
tissues to the bowel resulting in watery
diarrhea.
 There are two types of enterotoxin:

13. Toxins E.coli
Labile toxin
 Causes to increase outflow of water
and electrolytes in the gut lumen
causes Diarrhea

14. Toxins of E.coli
Stable Toxin
 ST A and ST B
 Causes fluid accumulation in Intestine.
 E.coli ( Some ) produce Verocytotoxin
causes cytotoxicity to Vero cells.
 Acts like Shigella dysentery toxin

15. Urinary Tract Infections
 E.coli produce urinary tract infection.
 Majority of UTI s are produce by E.coli.

16. E. Coli leading cause of
UTI
 Clinical significance
 Is the leading cause
of urinary tract
infections which
can lead to acute
cystitis (bladder
infection) and
pyelonephritis
(kidney infection).

17. Other infection with
E.coli
 Pyogenic infections.
 Intraabdominal infections
 Peritonitis.
 Septicemias
 Produce Drug resistant infections.

18. Other Important E. coli
Infection
 Neonatal meningitis – is the leading cause
of neonatal meningitis and septicemia
with a high mortality rate.

19. THANK YOU
Dr.T.V.Rao MD 19