This document discusses various topics related to surgical infections including: 1) Factors that increase surgical infection risk such as complicated/longer operations, immunosuppressed patients, and implant use. 2) Classification of surgical infections based on outcome, time of onset, and wound contamination risk. 3) Determinants of infection including microbial pathogenicity and host defenses. 4) Prevention strategies like proper patient preparation, strict asepsis, and prophylactic antibiotics. 5) Types of surgical infections affecting soft tissue or body cavities.

1. SURGICAL INFECTION Neil Mendoza, MD, FPSGS, FPCS

39. Antibiotic Mode of Action Cellular site of inhibition Bactericidal Bacteriostatic 1. Cell wall synthesis Penicillin Cephalosphorin Vancomysin Bacitracin 2. Barrier function of cell membrane Polymyxin B Colistin Amphotericin B Nystatin

40. Antibiotic Mode of Action Cellular site of inhibition Bactericidal Bacteriostatic 3. Protein synthesis in the ribosome Streptomycin aminoglycoside Tetracyclin Chloramphenicol Erythromycin Clindamycin 4. DNA replication in chromosome griseogulvin

55. Carbuncle

58. Necrotizing fascitis

77. ASEPSIS and ANTISEPSIS

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