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IRON DEFICIENCY  ANEMIA (IDA)
IRON 4 % of Earth’s Crust 4 ±1 gm  total Body Iron in Adult Human Hb 2± 0.5 gm Storage (Fe+++) 1  ± 0.5 gm Ferritin Haemos...
Variable ~ 450.000 Molecular  weight 37 20 % of iron in the structure Variable ~4500 iron atoms  /molecule of apof. Bindin...
Daily Iron Cycle
Enterocytes &Iron absorption
HEPCIDIN <ul><li>A polypeptide produced by the liver </li></ul><ul><li>The major hormonal regulator of </li></ul><ul><li>i...
 
 
Ancylostoma
Sequence of Events  in  IDA
SEQUENCE OF EVENTS IN IDA  I Hb 15  g/dL RCC  5 million/ µL MCH  30 pg Hct.  45  % MCHC  33 g/dL MCV  86 fL Serum Iron UIB...
SEQUENCE OF EVENTS IN IDA  II BLEEDING 40 ml/ Day 20 mg IRON Iron  Absorption up to 5  mg/Day Net Daily Loss=  20-5 = 15 m...
 
 
 
 
 
1/3  of  ACD are microcytic hypochromic Causes of microcytic hypochromic anemias The 1 st   step in the evaluation of micr...
 
 
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Iron deficiency anemia Slide 1 Iron deficiency anemia Slide 2 Iron deficiency anemia Slide 3 Iron deficiency anemia Slide 4 Iron deficiency anemia Slide 5 Iron deficiency anemia Slide 6 Iron deficiency anemia Slide 7 Iron deficiency anemia Slide 8 Iron deficiency anemia Slide 9 Iron deficiency anemia Slide 10 Iron deficiency anemia Slide 11 Iron deficiency anemia Slide 12 Iron deficiency anemia Slide 13 Iron deficiency anemia Slide 14 Iron deficiency anemia Slide 15 Iron deficiency anemia Slide 16 Iron deficiency anemia Slide 17 Iron deficiency anemia Slide 18 Iron deficiency anemia Slide 19 Iron deficiency anemia Slide 20
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Iron deficiency anemia

  1. 1. IRON DEFICIENCY ANEMIA (IDA)
  2. 2. IRON 4 % of Earth’s Crust 4 ±1 gm total Body Iron in Adult Human Hb 2± 0.5 gm Storage (Fe+++) 1 ± 0.5 gm Ferritin Haemosiderin Essential iron: Myoglobin & Iron-Containing Enz. (e.g.cytochromes, catalases) Plasma 4 ± 1 mg
  3. 3. Variable ~ 450.000 Molecular weight 37 20 % of iron in the structure Variable ~4500 iron atoms /molecule of apof. Binding Visible in macrophage & normoblasts Not visible In Perls’ - reaction (Prussian blue-reaction) under light microscope Derived from partial lysosomal digestion of aggregates of ferritin molecules Apoferritin ( outer prtn.coat ) & iron-phosphate- hydroxide core structure Insoluble Water-soluble Solubility Haemosiderin Ferritin Protein-iron complex
  4. 4. Daily Iron Cycle
  5. 5. Enterocytes &Iron absorption
  6. 6. HEPCIDIN <ul><li>A polypeptide produced by the liver </li></ul><ul><li>The major hormonal regulator of </li></ul><ul><li>iron homeostasis </li></ul><ul><li>It inhibits iron release from macrophages, intestinal epithelial cells & from placental syncytiotrophoblasts </li></ul><ul><li>by accelerating degradation of ferroportin mRNA </li></ul><ul><li>Iron deficiency , hypoxia & ineffective erythropoiesis </li></ul><ul><li>inhibits hepcidin production </li></ul><ul><li>iron release from pre-mentioned cells </li></ul><ul><li>As acute phase protein, </li></ul><ul><li>hepcidin production is induced by inflammation via IL-6 </li></ul>
  7. 9. Ancylostoma
  8. 10. Sequence of Events in IDA
  9. 11. SEQUENCE OF EVENTS IN IDA I Hb 15 g/dL RCC 5 million/ µL MCH 30 pg Hct. 45 % MCHC 33 g/dL MCV 86 fL Serum Iron UIBC 20 µmol/L 40 µmol/L TIBC= 60 µmol/L Saturation 33% p.ferritin N. 15-300 µg/L WBC 7,500/µL Platelet 400,000/µL
  10. 12. SEQUENCE OF EVENTS IN IDA II BLEEDING 40 ml/ Day 20 mg IRON Iron Absorption up to 5 mg/Day Net Daily Loss= 20-5 = 15 mg 1500 ------ = 100 Days 15 Latent Iron Deficiency No Clinical Features Normal Blood Values If Iron Stores= 1500 mg
  11. 18. 1/3 of ACD are microcytic hypochromic Causes of microcytic hypochromic anemias The 1 st step in the evaluation of microcytic anemia is to rule out IDA, HOW ?
  • BeneMallet

    Nov. 25, 2018
  • VijitRathod

    May. 10, 2017
  • BeLyn1

    Feb. 18, 2016
  • Fatentresh

    Jan. 28, 2016
  • YehyaKhawli

    May. 18, 2014

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