The document discusses medications used in poultry practice to prevent and treat avian diseases. It describes the aims of medications as the treatment of diseases, prevention of disease, improvement of performance, and anti-stress medication. It also provides definitions for terms like antibiotics, semi-synthetic antibiotics, and antibacterial agents. Finally, it notes that antibiotics and antibacterial agents can be classified based on their spectrum of activity, mode of action, absorption, and excretion.
Medications for Poultry Disease Prevention and Control
1. Medications
Medication is one of the most important veterinary tools that are used massively in poultry practice to
prevent and control avian diseases.
Aim of Medications
1-Treatment of serious treatable diseases.
Treatable avian diseases including: PD, fowl typhoid, fowl paratyphoid, arizonosis, Closterdial
diseases, FC, infectious serositis, spirochetosis, CCRD, IC, coccidiosis, histomoniasis,
trichomoniasis, avian malaria, aegeptenellosis and thrush.
2-Prevention of disease.
-Uses of antibiotics in chicken & turkeys to reduce the effect of mycoplasmosis.
-Uses of different anticoccidial drugs to prevent or reduce of coccidiosis.
-Uses of different anti-closterdial drugs to prevent necrotic enteritis, ulcerative enteritis and
gangrenous dermatitis.
-Use of the different anti-mycotoxins drugs to prevent or reduce of the different types of mycotoxins.
3-Improvement of performance.
-The use of certain antibiotics as Virginamycin and Flavomycin in feeds to improve weight gain,
decrease the feed conversion rate and increase the feed efficiency and egg production.
-The use of probiotics as Saccharomyces cervisae and Lactobacillus acidophilus in feed to improve
the weight gain, feed efficiency and egg production.
4-Anti-stress medication.
Stressors include transportation, handling, high ambient temperature, post-vaccinations, extreme cold,
severe chronic parasitism & crowding. Anti-stress medication is applied before, during or after the
period of stress to reduce the possible effects of infections resulting from reduced resistance. This
medication includes multivitamins + amino acids + minerals + antibiotics as tetracycline.
Such medication helps to over come or reduce the stress especiallywhere sub-optimal nutrition is present.
واﻟﺒﻜﺘﯿﺮﯾﺔ اﻟﺤﯿﻮﯾﺔ ﻣﻀﺎدات
واﻟﻄﯿﻮر اﻟﺤﯿﻮاﻧﺎت ﺗﺼﯿﺐ اﻟﺘﻲ اﻷﻣﺮاض ﻣﻦ اﻟﻌﺪﯾﺪ ﺿﺪ واﻟﻌﻼﺟﯿﺔ اﻟﻮﻗﺎﺋﯿﺔ اﻟﻮﺳﺎﺋﻞ أھﻢ ﻣﻦ واﻟﺒﻜﺘﯿﺮﯾﺔ اﻟﺤﯿﻮﯾﺔ ﻣﻀﺎدات ﺗﻌﺘﺒﺮ.
ﻋﺎﻣﺔ ﺗﻌﺮﯾﻔﺎت:
١-ﻣﻀﺎداتﺣﯿﻮﯾﺔAntibiotic:ھﻲﻣﯿﻜﺮوﺑﺎت ﻣﻦ ﺗﻔﺮز ﻛﯿﻤﯿﺎﺋﯿﺔ ﻣﻮادﻣﻌﯿﻨﺔﻀﺎداتﻣ وﺗﺸﻤﻞ أﺧﺮي ﻣﯿﻜﺮوﺑﺎت ﻧﻤﻮ ﺗﺜﺒﻂ أو ﻟﺘﻘﺘﻞ
ﺔاﻟﺤﯿﻮﯾﻼﻛﺴﯿﻠﯿﻨﺎتاﻟﺒﻨ ﻦﻣPenicillinsﺴﯿﻔﺎﻟﻮﺳﺒﻮروﻧﺎتواﻟCephalosporinsﯿﺪاتواﻷﻣﯿﻨﻮﺟﻠﯿﻜﻮﺳAminoglycosoides
ﯿﻜﻠﯿﺘﻮﻟﺰ واﻷﻣﯿﻨﻮﺳAminocyclytolesﺪات واﻟﻤﺎﻛﺮوﻟﯿMacrolidesﯿﻜﻠﯿﻨﺎت واﻟﺘﺘﺮاﺳTetracyclinesﺪات ﺑﺒﺘﯿ ﻮﻟﻲ واﻟﺒ
Polypeptidesاﻟﻜﻠﻮراﻣﯿﻔﯿﻨﻜﻮل وﻣﺠﻤﻮﻋﺔChloramephenicol group.
Antibiotic: A chemical substance produced by microorganism to kill or inhibit the growth of another
microorganism as penicillins, aminoglycosoides, aminocyclytoles and cephalosporin.
٢-ﺔﻣﺨﻠﻘ ﺼﻒﻧ ﺔﺣﯿﻮﯾ ﻀﺎداتﻣsynthetic antibiotics-Semi:اﻷ ﺾﺑﻌ ﺪﯾﻮﺟﺪﯾﻞﺗﻌ ﺘﻢﯾ ﻲاﻟﺘ ﺔاﻟﺤﯿﻮﯾ ﻀﺎداتﻣ ﻦﻣ ﻮاعﻧ
ﺔ اﻟﻤﺨﻠﻘ ﺼﻒ ﻧ ﺔ اﻟﺤﯿﻮﯾ ﻀﺎدات ﺑﻤ ﺴﻤﻲ وﺗ ﺔ ﻣﻌﻤﻠﯿ ﺔ ﺑﻄﺮﯾﻘ ﺔ اﻟﻔﺎرﻣﺎﻛﻮﻟﻮﺟﯿ ﺼﮭﺎ ﺧﺼﺎﺋ ﺴﯿﻦ وﺗﺤ ﺔ اﻟﺘﺮﻛﯿﺒﯿ ﺼﮭﺎ ﺧﺼﺎﺋSemi-
synthetic antibioticsاﻷﻣﯿﻨﻮﺑﻨﺴﯿﻠﯿﻨﺎت وﻣﻨﮭﺎ"واﻷﻣﻮﻛﺴﯿﺴﯿﻠﻠﯿﻦ اﻷﻣﺒﯿﺴﻠﯿﻦ"واﻟﻜﻠﯿﻨﺪاﻣﯿﺴﯿﻦ.
Semi-synthetic antibiotic: An antibiotic that is modulated in the laboratory as aminopenicillin and
clindamycine.
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11. ﻮروﻓﯿﻦ ﻛﻠ ﺪاي اﻟ ﻲ ھ ﺔ اﻟﻤﺠﻤﻮﻋ ﺬه ھ ﻢ وأھ ﺸﺮﯾﻄﯿﺔ اﻟ ﺪان اﻟﺪﯾ أو ﺔ اﻟﻜﺒﺪﯾ ﺪان اﻟﺪﯾ ﻼج ﻋ ﺪ ﻋﻨ ﻤﯿﺔ ﺳ ﻞ أﻗ ﻮن ﻟﺘﻜDichlorophan
واﻟﻨﺘﺮوﻛﺴﺎﻧﯿﻞNitroxynilﻓﯿﻨﻮﺛﯿﺪ واﻟﺪايDiamphenothide.
٦-ﺴﻠﻔﻮﻧﺎﻣﯿﺪاﻟ ﺔﻣﺠﻤﻮﻋSulphonamides:ﻀﺮﻣﺴﺘﺤ ﻞﻣﺜ ﺴﻠﻔﻮﻧﺎﻣﯿﺪاﻟ ﺔﻣﺠﻤﻮﻋ ﺮادأﻓ ﺾﺑﻌ ﺴﺘﻌﻤﻞﯾClorsulonﻼجﻋ ﻲﻓ
ﺑﺎﻟﻔﺎﺷﯿﻮﻻ أﺻﺎﺑﺘﮭﺎ ﻋﻨﺪ اﻷراﻧﺐ ﻓﻲ أﺳﺘﺨﺪاﻣﮫ اﻟﻤﻤﻜﻦ ﻣﻦ وﻟﻜﻦ اﻟﺪواﺟﻦ ﻓﻲ أﺳﺘﻌﻤﺎﻻت ﻟﮭﺎ وﻟﯿﺴﺖ ﻓﻘﻂ اﻟﺒﺎﻟﻐﺔ اﻟﻤﻔﻠﻄﺤﺔ اﻟﺪﯾﺪان.
٧-ﺔﻣﺠﻤﻮﻋphosphates-Organo:وﻟ ﺸﺮﯾﺔﺣ ﺪاتﻛﻤﺒﯿ ﺎأﺳﺎﺳ ﺔاﻟﻤﺠﻤﻮﻋ ﺬهھ ﺴﺘﻌﻤﻞﺗﺪان ﻟﻠﺪﯾ ﻀﺎداتﻛﻤ ﺴﺘﻌﻤﻞﺗ ﺎأﺣﯿﺎﻧ ﻦﻜ
ﻋﻤﻞ ﺗﻮﻗﻒ أﻧﮭﺎ ﺣﯿﺚ اﻷﺳﻄﻮاﻧﯿﺔ)ﺘﺮﯾﺰاﺳ ﻛﻮﻟﯿﻦ اﺳﯿﺘﯿﻞAcetyl choline esterase(ﻦوﻟﻜ ﺎوﻧﻔﻮﻗﮭ ﻠﻠﮭﺎﺷ ﻰاﻟ ﺆديﯾ ﺎﻣﻤ ﺪودةﻟﻠ
ﻰﻋﻠ ﺬﻟﻚﻛ ﺆﺛﺮﺗ ﺎأﻧﮭ ﺎﻋﯿﻮﺑﮭ)ﺘﺮﯾﺰاﺳ ﻮﻟﯿﻦاﻟﻜ(ﺘﻌﻤﺎﻟﮭأﺳ ﻒﺗﻮﻗ ﺬﻟﻚﻟ ﺪاﺟ ﻊﻣﺮﺗﻔ ﺎﻟﮭ ﺴﻤﯿﺔاﻟ ﺪﺣ ﺈنﻓ ﺬﻟﻚوﻟ ﻞﺑﺎﻟﻌﺎﺋ ﺎصاﻟﺨﻲﻓ ﺎ
ﻮس ﻛﻠﻮروﻓ ﺪاي اﻟ ﺎ أﻓﺮدھ ﻦ وﻣ ﻂ واﻟﻘﻄ ﻼب اﻟﻜ ﻲ ﻓ ﺘﻌﻤﺎﻟﮭﺎ إﺳ ﻦ ﯾﻤﻜ ﺎن ﻛ وأن ﺮة اﻟﻤﺠﺘ ﺎت اﻟﺤﯿﻮاﻧDichlorvos
واﻟﮭﺎﻟﻮﻛﺴﺎنHaloxonواﻟﺘﺮاﯾﻜﻠﻮروﻓﻮنTrichlorphon.
٨-ﺑﺒﺮازﯾﻦPiperazine:ﯾﺘ ﮫﻷﻧ ﻜﺎرساﻷﺳ ﺪاندﯾ ﺿﺪ ﺟﺪا ﻓﻌﺎل وﻟﻜﻨﮫ اﻟﺪواﺟﻦ ﻓﻲ اﻷﺳﻄﻮاﻧﯿﺔ ﻟﻠﺪﯾﺪان ﻛﻄﺎرد ﯾﺴﺘﻌﻤﻞﺎنﺑﺄﻣ ﻊﻤﺘ
ﯾﺘﻠﻮه أن ﯾﺠﺐ ﻟﺬا اﻟﻤﺨﻠﻔﺎت ﻣﻊ ﻃﺮدھﺎ ﻋﻠﻰ اﻷﻣﻌﺎء ﺗﻌﻤﻞ ﺛﻢ ﺷﻠﮭﺎ ﻋﻠﻰ ﯾﻌﻤﻞ ﺣﯿﺚ ﻓﻘﻂ اﻟﺒﺎﻟﻎ اﻟﻄﻮر ﻋﻠﻰ وﯾﺆﺛﺮ اﻷﺳﺘﻌﻤﺎل ﻋﻨﺪ ﻛﺎﻣﻞ
ﻓﯿﮭﺎ اﻟﺸﻠﻞ ﺣﺪوث اﻟﺪﯾﺪان ﻃﺮد ﻋﻠﻲ ﺗﺴﺎﻋﺪ ﺣﺘﻲ اﻷﻧﺠﻠﯿﺰي اﻟﻤﻠﺢ ﻣﻦ ﺟﺮﻋﺔ...ﺑﺎﻟﻐﺔ اﻟﻐﯿﺮ اﻟﺪﯾﺪان أو اﻟﯿﺮﻗﺎت ﻋﻠﻰ ﺗﺄﺛﯿﺮھﺎ ﻟﻌﺪم وﻧﻈﺮا
ﻓﺈﻧﮫﺑﻌﺪ اﻟﻌﻼج ﺗﻜﺮار ﯾﻠﺰم٤-٨ﺔواﻟﺠﺮﻋ ﺰﯾﻦاﻟﺒﺒﺮاﯾ ﻦﻣ اﻟﺘﺎﻟﯿﺔ ﺑﺎﻟﺠﺮﻋﺔ ﻣﻨﮭﺎ اﻟﺘﺨﻠﺺ ﻓﯿﺘﻢ اﻟﺼﻐﯿﺮة اﻷﻃﻮار ﺑﻠﻮغ ﯾﺘﻢ ﺣﺘﻰ أﺳﺎﺑﯿﻊ
ھﻲ ﻟﻠﺪواﺟﻦ ﺑﺎﻟﻨﺴﺒﺔ١٥٠-٢٥٠م ﻣﻠﺠﻢ.ف/أو اﻟﺸﺮب ﻣﯿﺎه ﻓﻲ ﺣﻲ وزن ﻛﺠﻢ٣-٥اﻟﻄﻦ ﻓﻲ ﻛﺠﻢ.
٩-ﻣﺼﻨﻔﺔ ﻏﯿﺮ دﯾﺪان ﻃﺎردات:واﻟﺒﻮﻧﺎﻣﯿﺪﯾ اﻟﻔﯿﻨﻮﺛﯿﺎزﯾﻦ ﺗﺸﻤﻞاﻟﺠﺮﻋﺎت ﻷن ﻧﻈﺮا ﺣﺎﻟﯿﺎ ﺗﺴﺘﻌﻤﻞ ﺗﻌﺪ وﻟﻢ اﻟﺪﯾﺪان ﻃﺎردات أﻗﺪم وھﻲ ﻦ
اﻟﻔﯿﻨﻮﺛﯿﺎزﯾﻦ ﺟﺮﻋﺔ ﻓﻤﺜﻼ ًاﺟﺪ ﻋﺎﻟﯿﺔ اﻟﻌﻼﺟﯿﺔ٦٠م ﺟﻢ.ف/وھﻲ اﻷﯾﻔﺮﻣﻜﺘﯿﻦ ﺑﺠﺮﻋﺔ ﺑﺎﻟﻤﻘﺎرﻧﺔ ﻛﺠﻢ٠٫٢ﻣﻠﺠﻢ/ﻛﺠﻢ.
اﻟﺪواﺋﯿﺔ اﻟﺘﺪاﺧﻼت
Drug Interaction
Introduction: In veterinary practice especially in poultry sector, a lot of drugs are used for
prevention and treatment of diseases. Sometimes, two or more of drugs are used together either in
mixtures or simultaneously "combination therapy". This is intended for maximizing the efficacy of
drugs to attain a successful control of the complicated diseased conditions. Uses of mixed drugs
without knowledge about the drug interactions are filled with dangers.
Aims of combination therapy:
1-Treatment of mixed bacterial infection in which the causative agents are not susceptible to certain
specific antibacterial drug.
2-Prevention of the microbial resistance to anti-microbial agents.
3-Prevention of the drug toxicities.
4-Counteract the effect of the adaptive microbial enzymes that inactivates certain antibiotics. B-
lactimase "certain penicillins & cephalosporins" and acetylase & phosphorylases "in
aminoglycosoides".
Drug interaction: it is the interaction occurring between two drugs or more when they are used in
mixture or simultaneously. It may lead to very good creative results or unwanted negative results
"inactivation, toxicity or side effects".
Forms of drug interactions:
I-Direct drug-drug interactions.
II-Drug feed interactions.
III-Pharmacokinetic interaction.
IV-Pharmacodynamic interaction.
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12. I-Direct drug-drug interactions
اﻟﻤﺒﺎﺷﺮ اﻟﺪواﺋﻲ اﻟﺘﺪاﺧﻞ
It depends on the direct chemical and/or physical interaction the active principles themselves or the
carriers themselves or the active principles and carriers hence called "Drug interaction at the
pharmaceutical phase". It occurs in-vitro or in-vivo.
Drug A + Drug B →
Direct drug-drug interactions
In-vitro In-vivo
Mechanisms of direct drug interactions:
I-Chemical reactivity. II-Physical adsorption. III-Chelation.
This type of drug interaction includes:
1-Mixing of acidic drugs with basic drugs: This is may lead to precipitation and inactivation of one
or both drugs. One point should be taken in consideration that this reaction will be inhibited when the
acidic or basic drugs are present in salt formula.
Table showing different acidic, basic and amphoteric drugs:
Acidic drugs Amphoteric drugs Basic drugs
Penicillins Morphine
Cephalosporins Aminoglucosoides
Sulfonamides Aminocyclitols
Nitrofurans
Tetracyclines are amphoteric but tend
to be more basic in nature.
Macrolides
Probencid Lincosamides
Aspirin Procaine
Indomethacin Trimethoprime
Ibuprofen
Quinolones are amphoteric but tend to
be more acidic in nature.
Piprazine
Thiophylin Atropine
Adrenaline Metronidazole
Heparin Chloramphinicol
Fursemide Colistin
Refampicin
Aminopenicillins are amphoteric but
tend to be more acidic in nature.
Antihistaminics
1-Inactivation "chemically"
2-Chelation "chemically"
3-Adsorption "physically"
4-Another product
5-No reaction at all
Direct
mixing in
one
syringe
Direct
mixing in
one drinking
water tank.
Direct
mixing in
one ration
Direct
mixing in
GIT
Direct
mixing at
the site
infection
Direct
mixing in
venous
circulation
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13. 2-Mixing of incompatible drugs:
Drugs Incompatible with
Gentamycin 1-Carbenicillin & other semi-synthetic penicillins "irreversible reaction".
2-The 1st
generation of cephalosporins for fear of severe nephrotoxicities.
2-The 2nd
& 3rd
generation of cephalosporins "chemical inactivation".
3-Chloramphinicol sod.succinate.
4-Sulfonamides.
Chloramphinicol
sod.succinate
Hydrocortizone sod.succinate - Penicillins – Heparin Tetracyclines -
Gentamycin Sulphate – Macrolides – Vitamin B–complex and vitamin C –
Sulfonamides - Colistin sulphate.
Penicillins Amphotracin B - Chlorophnramine malate – Dexamethazone – Heparin -
Chloramphinicol sod.succinate – Tetracyclines and Phenobarbital.
Mixing of incompatible drugs "continued":
Drugs Incompatible with
Ampicillin sod. -Glucose solution - Dextran solution – Aminoglucosoides - Colistin
sulphate.
Tetracyclines Solutions of polyvalent cations "chelation" – Penicillins – Cephalosporins -
Chloramphinicol sod.succinate - Hydrocortizone sod.succinate-
Sod.bicarbonate.
Sod.bicarbonate Tetracyclines - Solutions of polyvalent cations due to chelation.
Kanamycin 1-Methicillin at the site of infection.
Activated charcoal 1-Most drugs in the GIT due to chelation.
Sulfonamides Calcium gluconate "gel formation" – Gentamycin - Chloramphinicol sod.
succinate.
II-Drug feed interactions اﻟﻐﺬاﺋﻲ اﻟﺪواﺋﻲ اﻟﺘﺪاﺧﻞ
Feeds inside the GIT are known to react with some drugs and the reverse is true.
A-Effect of feed on the drugs:
I-Reduce the absorption of certain drugs as ampicillin, cephalosporins, sulfonamides,
Lincomycine and rifampicin.
II-High fat content of feed increase the absorption of grisofulvin.
III-Feeds containing polyvalent cations causes chelation of tetracyclines.
B-Effect of drugs on feeds:
1-Aminsteration of mineral oils reduces the absorption of fat soluble vitamins & grisofulvin.
2-Certain antibiotics "when given orally for long time" e.g. tetracyclines, oral active penicillins and
aminoglucosoides negatively affect the growth of intestinal microflora leading to reduction of
biosynthesis of microbial vitamins "B-complex & K".
EffectsInteracting drugsDrug
Lincomycin
Ampicillin
Tetracyclines
Rifampicin
Decrease the absorption of the
interacting drugs.
1st
generation of cephalosporins
Feed
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