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Ticagrelor: Experience in STEMI & NSTEMI & UA ACS cases in ED Ramathibodi hospital 
Yuwares Sittichanbuncha.Assist.Prof. 
Emergency Department 
Ramathibodi Hospital Medical School 
Mahidol University
ห้องฉุกเฉิน โรงพยาบาลรามาธิบดี
ห้องกู้ชีพ1, 2 
ห้องตรวจ 
จุดคัดกรอง 
ห้องทำกำร รักษำ 
ห้องสังเกต อำกำร 
ห้องX-ray
Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). European heart journal. 2011;32(23):2999-3054.
ผู้ป่วยหญิงอายุ 66 ปี underlying DM,HT มาห้องฉุกเฉิน ด้วยอาการจุกลิ้นปี่ 30 นาทีก่อนมาโรงพยาบาล
CPG Acute MI 
•Multidisciplinary collaboration: ER, Cardio-medicine, Pathology 
•Lean Operation: One stop service 
•CQI 
•Evidence based medicine
CPG Acute MI
Chest pain prevalence in Rama ED 
2011 
2012 
2013(6mos) 
CC: Chest pain 
858 
906 
376 
Acute MI 
115 (12%) 
111 (12.25%) 
59 (15.7%)
•Conclusion from PLATO trial 
•Primary endpoint: Death from vascular causes(MI,CVA) ,Mortality ,MI ,Stent thrombosis decrease in Tecagrelor group 
•CVA, Major Bleeding no dfference between Tecagrelor and Clopidogrel
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary 
by Patrick T. O’Gara, Frederick G. Kushner, Deborah D. Ascheim, Donald E. Casey, Mina K. Chung, James A. de Lemos, Steven M. Ettinger, James C. Fang, Francis M. Fesmire, Barry A. Franklin, Christopher B. Granger, Harlan M. Krumholz, Jane A. Linderbaum, David A. Morrow, L. Kristin Newby, Joseph P. Ornato, Narith Ou, Martha J. Radford, Jacqueline E. Tamis-Holland, Jacqueline E. Tommaso, Cynthia M. Tracy, Y. Joseph Woo, and David X. Zhao 
Circulation 
Volume 127(4):529-555 
January 29, 2013 
Copyright © American Heart Association, Inc. All rights reserved.
Inhibition of platelet reactivity 
Gurbel PA, et al. Circulation. 2009;120:2577-2585. 
[Gurbel 2009:B] 
IPA, inhibition of platelet activity
Inhibition of platelet reactivity 
Gurbel PA, et al. Circulation. 2009;120:2577-2585. 
[Gurbel 2009:B] 
IPA, inhibition of platelet activity
Steg PG, James S, Harrington RA, et al. Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation.2010;122:2131– 41.
คาถาม สาหรับ กูรู 
•ข้อแนะนาสาหรับแพทย์ หากพบกรณีเช่นนี้ที่ รพช. ก่อน refer ? 
•Antiplatelet of choice? 
•Take home message?
คิดถึง ER…คิดถึง รามาธิบดี...

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ACTEP2014: Symp Experience in STEMI & NSTEMI & UA ACS cases in ED Ramathibodi Hospital

  • 1. Ticagrelor: Experience in STEMI & NSTEMI & UA ACS cases in ED Ramathibodi hospital Yuwares Sittichanbuncha.Assist.Prof. Emergency Department Ramathibodi Hospital Medical School Mahidol University
  • 3. ห้องกู้ชีพ1, 2 ห้องตรวจ จุดคัดกรอง ห้องทำกำร รักษำ ห้องสังเกต อำกำร ห้องX-ray
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  • 5. Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). European heart journal. 2011;32(23):2999-3054.
  • 6. ผู้ป่วยหญิงอายุ 66 ปี underlying DM,HT มาห้องฉุกเฉิน ด้วยอาการจุกลิ้นปี่ 30 นาทีก่อนมาโรงพยาบาล
  • 7. CPG Acute MI •Multidisciplinary collaboration: ER, Cardio-medicine, Pathology •Lean Operation: One stop service •CQI •Evidence based medicine
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  • 17. Chest pain prevalence in Rama ED 2011 2012 2013(6mos) CC: Chest pain 858 906 376 Acute MI 115 (12%) 111 (12.25%) 59 (15.7%)
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  • 22. •Conclusion from PLATO trial •Primary endpoint: Death from vascular causes(MI,CVA) ,Mortality ,MI ,Stent thrombosis decrease in Tecagrelor group •CVA, Major Bleeding no dfference between Tecagrelor and Clopidogrel
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  • 25. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary by Patrick T. O’Gara, Frederick G. Kushner, Deborah D. Ascheim, Donald E. Casey, Mina K. Chung, James A. de Lemos, Steven M. Ettinger, James C. Fang, Francis M. Fesmire, Barry A. Franklin, Christopher B. Granger, Harlan M. Krumholz, Jane A. Linderbaum, David A. Morrow, L. Kristin Newby, Joseph P. Ornato, Narith Ou, Martha J. Radford, Jacqueline E. Tamis-Holland, Jacqueline E. Tommaso, Cynthia M. Tracy, Y. Joseph Woo, and David X. Zhao Circulation Volume 127(4):529-555 January 29, 2013 Copyright © American Heart Association, Inc. All rights reserved.
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  • 27. Inhibition of platelet reactivity Gurbel PA, et al. Circulation. 2009;120:2577-2585. [Gurbel 2009:B] IPA, inhibition of platelet activity
  • 28. Inhibition of platelet reactivity Gurbel PA, et al. Circulation. 2009;120:2577-2585. [Gurbel 2009:B] IPA, inhibition of platelet activity
  • 29. Steg PG, James S, Harrington RA, et al. Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation.2010;122:2131– 41.
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  • 34. คาถาม สาหรับ กูรู •ข้อแนะนาสาหรับแพทย์ หากพบกรณีเช่นนี้ที่ รพช. ก่อน refer ? •Antiplatelet of choice? •Take home message?