27. 7
The two Death Valleys of the clinical
translational continuum
Capacity to translate research results to the next stage, affecting, first, our
ability to commercialize research results (Valley 1), and, second, our
effectiveness at moving results into clinical practice (Valley 2)
www.cihr-irsc.gc.ca/e/41232.html
30. *- -7,1
,12 (PCI)
Value:
*? American College of Cardiology Foundation
(ACC) ', American Heart Association Guideline (AHA) (#O
P secondary prevention
Aspirin/Clopidogrel
C0
39. Literature Review
Standardized work (Checklist)
12
Benefit of Post PCI Medical Checklist to
Improve Adhering with Best Practice
Guidelines in the Patients with Coronary
artery disease undergoing Percutaneous
Coronary Intervention (PCI)
101. Combined 2.5%
Phenylephrine and
0.75%Tropicamide
Double-blind Randomized controlled trial
Patients
# of Pupil size 7
mm
# of Pupil size 7
mm
40 min and 120 min
Primary Outcome: Number of patients whose pupil
reached 7 mm. within 40 minutes
102. Results
Outcomes
Sequential
drug
(n=18)
Combined
drug (n=22)
p -
value
Number of patients whose pupil
reached 7 mm. within 40 minutes 38.9% 77.3% 0.02
Pupil size: mean ± SD (mm.)
At 40 minutes
At 2 hours
6.0 ± 0.9
6.7 ± 0.8
6.6 ± 0.8
6.8 ± 0.9
0.03
0.44
For the combined drug, Time to pupil size 7 mm = 32 min (mean)
Blood pressure and pulse rate were stable and similar in both
groups.
“g/+2 +#!
!^C0
107. Medical Institute of the Kingdom
toward International Excellence
Human Capital
Excellence
Routine work
Clinical
Excellence
Knowledge
Creation
Clinic
(Front office)
Innovation
Publication
Knowledge
Translation
Support
(Back office)
Quality Criteria e.g. HA, JCIA TQA
41
!
-
5
109. -Workflow (input process output)
• Care team: care process
• Laboratory: Specimen collection, preparation, obtain, handling, storage,
process, report
• Lean: Value Stream Mapping
• Siriraj Clinical Tracer + (SiCT+)
2. 1%* + -Complaint incidence
• What have happened
• What/How factors associated with the incidence
• What should be the solution / What is the best way to solve the problem
• 4 #+
$%(%6
0 “6 ”
3. *!#[-Indicators (process, output, outcome)
• Target, Timing
• Other institute/Best practice
• Criteria (HA/JCIA/ISO)
4.
711 +-Organizational goal (s)
42