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Calcitonin
DANISH HASSAN
LECTURER, UNIVERSITY OF SARGODHA
Calcitonin
 Secreted by the parafollicular cells or clear cells
(C cells), situated amongst the follicles in thyroid
gland.
 In lower animals, the parafollicular cells.
Calcitonin
 Chemistry and Synthesis
 Calcitonin is a polypeptide chain with 32 amino
acids. Its molecular weight is about 3,400.
 It is synthesized from procalcitonin
 Plasma Level and Half-life
 Plasma level of calcitonin is 1 to 2 ng/dL.
 It has a halflife of 5 to 10 minutes
 Metabolism
 Calcitonin is degraded and excreted by liver and
kidney
 Actions Of Calcitonin
 Plays an important role in controlling the blood calcium
level.
 It decreases the blood calcium level and thereby
counteracts parathormone.
 Calcitonin reduces the blood calcium level by acting
on:
 Bones
 Kidneys
 Intestine
 On bones
 Calcitonin stimulates osteoblastic activity and
facilitates the deposition of calcium on bones.
 At the same time, it suppresses the activity of
osteoclasts and inhibits the resorption of calcium
from bones.
 It inhibits even the development of new osteoclasts
in bones
 On kidney
 Increases excretion of calcium through urine, by
inhibiting the reabsorption from the renal tubules
 On intestine
 Prevents the absorption of calcium from intestine
into the blood.
 On Blood Phosphate Level
 With respect to calcium, calcitonin is an antagonist
to PTH.
 But it has similar actions of PTH, with respect to
phosphate.
 It decreases the blood level of phosphate by acting
on:
1. Bones
2. Kidneys
 On bones
 Inhibits the resorption of phosphate from bone and
stimulates the deposition of phosphate on bones.
 On kidney
 Calcitonin increases the excretion of phosphate
through urine, by inhibiting the reabsorption from
renal tubules
 Regulation Of Calcitonin Secretion
 High calcium content in plasma stimulates the
calcitonin secretion through a calcium receptor in
parafollicular cells.
 Gastrin also is known to stimulate the release of
calcitonin.

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Calcitonin

  • 2. Calcitonin  Secreted by the parafollicular cells or clear cells (C cells), situated amongst the follicles in thyroid gland.  In lower animals, the parafollicular cells.
  • 4.  Chemistry and Synthesis  Calcitonin is a polypeptide chain with 32 amino acids. Its molecular weight is about 3,400.  It is synthesized from procalcitonin
  • 5.  Plasma Level and Half-life  Plasma level of calcitonin is 1 to 2 ng/dL.  It has a halflife of 5 to 10 minutes
  • 6.  Metabolism  Calcitonin is degraded and excreted by liver and kidney
  • 7.  Actions Of Calcitonin  Plays an important role in controlling the blood calcium level.  It decreases the blood calcium level and thereby counteracts parathormone.  Calcitonin reduces the blood calcium level by acting on:  Bones  Kidneys  Intestine
  • 8.  On bones  Calcitonin stimulates osteoblastic activity and facilitates the deposition of calcium on bones.  At the same time, it suppresses the activity of osteoclasts and inhibits the resorption of calcium from bones.  It inhibits even the development of new osteoclasts in bones
  • 9.  On kidney  Increases excretion of calcium through urine, by inhibiting the reabsorption from the renal tubules
  • 10.  On intestine  Prevents the absorption of calcium from intestine into the blood.
  • 11.  On Blood Phosphate Level  With respect to calcium, calcitonin is an antagonist to PTH.  But it has similar actions of PTH, with respect to phosphate.  It decreases the blood level of phosphate by acting on: 1. Bones 2. Kidneys
  • 12.  On bones  Inhibits the resorption of phosphate from bone and stimulates the deposition of phosphate on bones.
  • 13.  On kidney  Calcitonin increases the excretion of phosphate through urine, by inhibiting the reabsorption from renal tubules
  • 14.  Regulation Of Calcitonin Secretion  High calcium content in plasma stimulates the calcitonin secretion through a calcium receptor in parafollicular cells.  Gastrin also is known to stimulate the release of calcitonin.