5. EPIDEMIOLOGY
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6% Prevalence Rate in Clinics
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Endemic to India
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20 - 40 yrs.
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Male : female = 5 :1
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Urban, sexual promiscuity, low socio- economic
status.
6. AETIOLOGY
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Chlamydia Biovar LGV Serovar L1/L2/L3
โข
Obligate intracellular, Gram negative bacillus with
humans as Natural Hosts by Sexual Transmission /
Perinatal infection
โข
Intracytoplasmic inclusion bodies
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Controls the organelles of host cells for own growth
and protein synth
โข
Cell cycle โ 48 to 72 hrs
8. PATHOGENESIS
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โข
โข
โข
โข
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Entry into cell as Metabolically inactive
elementary body (Eb) by receptor mediated
endocytosis.
Conversion to Active Reticulate Bodies which
multiply , condense and form Eb ๏ burst out of
host cells
Lymphangitis, perilymphangitis, necrosis of
lymph nodes
PMN stellate abscess- bubo
Healing by fibrosis - esthiomene, adhesions
Dissemination rare
16. SECONDARY STAGE
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โStage of Diagnosisโ
? Women
Dissemination (Rare, hematogenous)
โข
Arthritis
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Ocular inflammatory disease
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Pneumonitis
โข
Hepatitis
โข
EN / EM
17. TERTIARY STAGE
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โข
Develops in 25% of untreated
GENITO-ANO-RECTAL syndrome, more common in
women / MSM
Clinical features
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โข
Hyperplastic Ulcerative lesions
Proctocolitis
โข Bloody purulent discharge
โข Pruritis Ani
โข Tenessemus
23. Extragenital manifestations
๏จ
Ocular manifestations
โข
Can occur at any stage
common with L2
Conjunctivitis, Episcleritis, Keratitis, Iritis
Submaxillary, post auricular LN
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โข
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๏จ
Cutaneous manifestations
Id eruptions
Ilio-Psoas Abscess
27. Management
๏จ
General measures
๏จ
Medical Cap Doxycycline 100 mg bd
Tab Erythromycin 500 mg qid
Tab Azithro 1gm/wk
๏ถ
21days
Erythromycin 7.5- 12.5 mg/kg qid for 2-3wk for
children and pregnant patients
28. ๏จ
Surgical
Bubo aspiration preferred over I & D
Sx - elephantiasis, esthiomene, sinus,
fistulae,
stricture dilatation
๏จ
Partner management (All contacts in 60
days)
azithromycin 1 gm orally single dose or
doxycycline 100 mg BD X 07 days