Toxicocinética: conceptos, modelos y cálculos
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Toxicologia: Toxicocinetica
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Toxicocinética: conceptos, modelos y cálculos
- 6. MODELOS COMPARTIMENTALES REPETTO 2007
- 18. Cálculos en Toxicocinética Formulas : 21. Vd = Qo / Kel . Abc 22. t ½ = 0.693 / Kel = 0.693 / β 23. T máx. = 1 / Kel 24. – dC / dt = Vm. C / Km (cinética de óden cero 25. Cl = Cu x V / Cp (aclaramiento) 26. Cl = Qe / Cp = Kel x Qo / Cp 27. Cl = Kel x Vd = Qo / Abc 28. Cl total = Kel x Vd x peso corporal 29. Log C = -Ka x t / 2.303 + log Co
- 26. Cálculos en Toxicocinética In Cp = InCp (o) – Kel - Kel = (In 35.7 – In 45.5) / (6-2) = (3.58 – 3.82) / 4 - Kel = -0.24 /4 = - 0.06 Kel = 0.06 In Cp(2Hr) = In Cp(o) – Kel x t In 45.5 = In Cp(o) – 0.06 x 2 In Cp(o) = 3.82 + 0.12 = 3.94; Cp(o) = 51.4 = dosis / V Vd = dosis /Cp(o) = 800 & 51.4 = 156 [L] t ½ = 16.5
- 40. Cálculos en Toxicocinética A = dosis absorbida 25 ml x 20 ml/100 ml = 25 x 0.2 = 5 ml etanol absoluto Información: densidad de etanol 0.8 Vd = 0.7 = 5 ml x 0.8 g/ml = 4.0 g = 4000 mg Cp = A /Vd x peso corporal = 4000 /0.7 x 16 = 357.14 mg Cp = 35.71 mg %