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Code Pink
What to think about when running up
           to Delivery Suite

    A summary of the Australian
   Resuscitation Council Guidelines
     For Newborn Resuscitation
Australian Resuscitation Council
           Guidelines
   http://www.resus.org.au
The transition from fetus to
newborn requires intervention by a
   skilled individual or team in
approximately 10% of all deliveries.
Keep warm
Hypothermia on admission to the neonatal unit
 has been shown to be associated with an
 increased mortality. It is essential to prevent
 excessive heat loss in the delivery room and
 throughout stabilization and transport to the
 neonatal unit.
Keep Warm


Hypothermia can increase oxygen
    consumption and impede
      effective resuscitation
Axillary Temperatures in Infants
          Weighing Less Than 1500 gm
Ranges                  Temperature    Action Needed

Normal                  36.5-37.5o C   Continue

Potential cold stress   36-36.5o C     Cause for concern

Moderate hypothermia    32-36o C       Danger; immediate
                                       warming of baby needed
Severe hypothermia      < 32o C        Outlook grave; skilled
                                       care urgently needed
Keep Warm
ā€¢ Newborns should be dried with pre-warmed
  blankets or towels and placed on a pre-warmed
  heat source. Open bed warmers, which use
  radiant heat, are used in most delivery rooms.
  They provide warmth during resuscitation and for
  any subsequent invasive procedures. It is
  important to keep in mind that this source of
  heat does not protect the infant from evaporative
  heat loss but, instead, encourages evaporative
  heat losses.
Keep Warm
ā€¢ Continuous monitoring of temperature should
  occur as soon as possible after the delivery.
  Premature infants (< 1500 g) should be
  covered in plastic wrap (polyethylene) to
  prevent excessive heat loss. A full
  resuscitation, including line placement, can
  and should be performed with the plastic
  wrap in place. A woolen head cap should be
  used.
Keep Warm
ā€¢ Another common source of heat loss in the
  neonate undergoing resuscitation is the use of
  unheated non-humidified oxygen sources for
  the bag-valve-mask device. The inspired gases
  sent to the lungs are subsequently heated and
  humidified by the infant; this results in
  massive heat exchange from evaporative heat
  loss and insensible water loss. Whenever
  possible, warmed and humidified gases should
  be provided in the resuscitation area.
Airway management

ā€¢ Once in a heated environment, the infant
  should be positioned so as to open the airway,
  and the mouth and nose should be suctioned.


ā€¢ Should suction involve larynx
  and Trachea?
Easy answer is no!!
ā€¢ Infants have a vagal reflex response to sensory
  stimulation of the larynx, which may induce
  apnea, bradycardia, hypotension, and
  laryngospasm.
ā€¢ Suctioning the posterior oral airway or the
  trachea with a catheter because of extremely
  thick or meconium-stained fluids may cause
  profound central apnea, potentially profound
  bradycardia, and laryngospasm
Suctioning
ā€¢ Instillation of saline into the trachea also has
  been shown to stimulate the afferent sensory
  neurons leading to apnea, bradycardia,
  hypotension, and laryngospasm.
ā€¢ Suctioning the posterior oral airway or the
  trachea consequently has no place in the
  immediate resuscitation period.
ā€¢ Lung inflation has been shown to reverse the
  effects of vagal stimulation.
Code Pink
  If called to Delivery suite
Heart Rate is the critical sign.
         >100 is crucial
Bradycardia is Bad
ā€¢ Normal Newborn HR is 100-160

ā€¢ HR below 100 requires Positive Pressure
  Ventilation and Pulse Oximetry
ā€¢ This is irrespective of normal or abnormal
  Respiratory effort
Why is Bradycardia bad?
ā€¢ A fetus or newborn that is subjected to
  asphyxia initiates a "diving" reflex in an
  attempt to maintain perfusion and oxygen
  delivery to vital organs. Hypoxia and acidosis
  lead to pulmonary arteriolar vasoconstriction.
  Pulmonary vascular resistance increases,
  leading to decreased pulmonary blood flow
  and increased blood flow directly to the left
  atrium.
Why is Bradycardia bad?
ā€¢ Systemic cardiac output is redistributed, with
  increased flow to the heart, brain, and adrenal
  glands and decreased flow to the rest of the
  body. Early in the course of asphyxia, systemic
  blood pressure increases.
ā€¢ With ongoing hypoxia and acidosis, however, the
  myocardium fails and bradycardia occurs; this
  causes a decrease in blood pressure and tissue
  perfusion, leading to eventual tissue ischemia
  and hypoxia.
ā€¢ With prolonged asphyxial insult
  and failure of compensatory
  mechanisms, cerebral blood flow
  falls, leading to ischemic brain
  injury
What about Oximetry?

 ā€¢Is a cyanosed Newborn
          normal?
Targeted pre-ductal SpO2 after birth
ā€¢   1min            60-70%
ā€¢   2min            65-85%
ā€¢   3min            70-90%
ā€¢   4min            75-90%
ā€¢   5min            80-90%

ā€¢ 10min             85-90%
Changes in circulation after birth
Reversal of right to left shunting
ā€¢ Clamping of the umbilical cord removes the low-resistance
  placental vascular circuit and thereby raises total systemic
  vascular resistance, with a resultant increase in left
  ventricular and aortic pressures. The increased systemic
  vascular resistance, combined with the decreased
  pulmonary vascular resistance, reverses the shunt through
  the ductus arteriosus (from right-to-left shunting to left-to-
  right shunting) until the ductus closes completely.
ā€¢ All of these events result in closure of the other fetal
  shunts. With the decrease in right atrial pressure and the
  increase in left atrial pressure, the 1-way "flap-valve"
  foramen ovale is pushed closed against the atrial septum.
  This functional closure at birth is followed by anatomic
  closure, which usually occurs at several months of age.
ā€¢ Functional closure of the ductus arteriosus
  generally occurs within 72 hours of life, with
  anatomic closure by age 1-2 weeks.
ā€¢ Functional postnatal circulation generally is
  established within 60 seconds; however,
  completion of the transformation can take up
  to 6 weeks.
How to correct Bradycardia
ā€¢ PPV using Neopuff

ā€¢ 5cm PEEP (Positive End Expiratory Pressure)
ā€¢ 30cm PIP (Peak Inspiratory pressure)
ā€¢ Settings should already be made on resus
  trolley
PPV
ā€¢ Ventilatory rates of 40-60 breaths/min should
  be provided initially, with proportionally fewer
  assisted breaths provided if the infant's
  spontaneous respiratory efforts increase.
NEOPUFF
NEOPUFF
What to do if HR< 60
ā€¢ Commence Chest compressions

ā€¢ 100% O2

ā€¢ Intubation or LMA
HR< 60
Chest compressions should be initiated after
only 30 seconds of effective PPV if the heart
rate remains below 60 beats/min.
Chest Compressions
Chest Compressions
ā€¢ Pressure should be applied to the lower portion
  of the sternum, depressing it to a depth of about
  one third of the anterior-posterior diameter. The
  chest should fully re-expand during relaxation.
  One ventilation should be interposed after every
  3 chest compressions.
ā€¢ An overall rate of 120 compression/ventilation
  events per minute is recommended; with the 3:1
  compression-to-ventilation ratio, this equates to
  90 compressions and 30 breaths each minute.
Chest Compressions
ā€¢ Evaluate heart rate and color every 30
  seconds. Infants who fail to respond may not
  be receiving effective ventilatory support;
  thus, constantly evaluating ventilation is
  imperative. Chest compressions should be
  discontinued when the heart rate is 60
  beats/min or higher.
Intubation
ā€¢ If things still not going well
  then intubation required
Intubation
    Blade size 0 or 1 should be chosen in accordance with the size of
    the infant. Premature infants may be more easily intubated with a
    size 0 blade, and term infants require a size 1 blade.
    Endotracheal tube should be chosen in accordance with the weight
    of the infant .
ā€¢   Table 3. Endotracheal Tube Size and Measurement at Lip According
    to Infant Weight
ā€¢   Infant Weight         Endotracheal Tube Size           Endotracheal
    Tube Measurement at Lip
ā€¢   < 1000 g              2.5                       7 cm
ā€¢   1000-2000 g           2.5-3                     8 cm
ā€¢   2000-3000 g           3-3.5                     9 cm
ā€¢   > 3000 g              3.5-4                     10 cm
Intubation
ā€¢ Another way of estimating correct placement
  of the ET tube is to take the weight of the
  infant in kilograms and add 6 to yield the
  number of centimeters at which the tube
  should be secured at the lip.
Intubation
ā€¢ Assessment for equal bilateral breath sounds
  with maintenance of oxygenation.
ā€¢ An increase in the heart rate within 5-15
  seconds is an excellent indicator of adequate
  ventilation and appropriate ET tube
  placement.
Intravenous Access
ā€¢ Needed for Volume expansion

ā€¢ Administration of Adrenaline
Intravenous Access
ā€¢ Peripheral Venous access

ā€¢ Umbilical Vein Catheterisation

ā€¢ Intraosseous access generally not
  recommended (Too small intramedullary
  space and fragile bones)
Intravenous Access
ā€¢ Umbilical vein catheterization may be a life-
  saving procedure in neonates who require
  vascular access and resuscitation.
ā€¢ The umbilical vein remains patent and viable
  for cannulation until approximately 1 week
  after birth
Umbilical Vein Catheterisation
Umbilical Vein Catheterisation
ā€¢ Advance the catheter only 1-2 cm beyond the
  point at which good blood return is obtained.
  This is approximately 4-5 cm in a full-term
  neonate.
Umbilical Vein Catheterisation
ā€¢ Secure the catheter with a suture through the
  cord, marker tape, and a tape bridge.
ā€¢ The position of the catheter must be
  confirmed radiographically. A properly placed
  umbilical vein catheter appears to travel
  cephalad until it passes through the ductus
  venosus
Adrenaline
ā€¢ The recommended dose is 0.01-0.03 mg/kg
  (0.1-0.3 mL of the 1:10,000 solution),
  preferably administered intravenously (IV).
  Higher IV doses are not recommended
Adrenaline
ā€¢ If you are too overwhelmed and canā€™t think
ā€¢ Easy tip to remember is that average newborn
  in size will need

 1ml of 1:10,000
 Adrenaline
Adrenaline
ā€¢ If vascular access cannot be obtained,
  Adrenaline may be given via the ET tube
ā€¢ The dose should be increased to 3 times the IV
  dose. Followed with infusion of 0.5-1 mL of
  saline to ensure that the drug is delivered to
  the lung, where it is absorbed and delivered to
  the heart.
Volume Expansion
ā€¢ Suspected Blood loss
ā€¢ Pale poor perfusion or weak pulse
ā€¢ Not responded to other resuscitative
  measures


  10ml/kg IV push over
  few minutes
Anything else?
ā€¢ ā€œDEFGā€ Donā€™t ever forget Glucose

 If glucose low, administer 5ml/kg 10%
 Dextrose and recheck
What Next?

ā€¢Get as much help as
 possible locally
ā€¢NETS retrieval to NICU

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Code pink

  • 1. Code Pink What to think about when running up to Delivery Suite A summary of the Australian Resuscitation Council Guidelines For Newborn Resuscitation
  • 2. Australian Resuscitation Council Guidelines http://www.resus.org.au
  • 3.
  • 4. The transition from fetus to newborn requires intervention by a skilled individual or team in approximately 10% of all deliveries.
  • 5. Keep warm Hypothermia on admission to the neonatal unit has been shown to be associated with an increased mortality. It is essential to prevent excessive heat loss in the delivery room and throughout stabilization and transport to the neonatal unit.
  • 6. Keep Warm Hypothermia can increase oxygen consumption and impede effective resuscitation
  • 7. Axillary Temperatures in Infants Weighing Less Than 1500 gm Ranges Temperature Action Needed Normal 36.5-37.5o C Continue Potential cold stress 36-36.5o C Cause for concern Moderate hypothermia 32-36o C Danger; immediate warming of baby needed Severe hypothermia < 32o C Outlook grave; skilled care urgently needed
  • 8. Keep Warm ā€¢ Newborns should be dried with pre-warmed blankets or towels and placed on a pre-warmed heat source. Open bed warmers, which use radiant heat, are used in most delivery rooms. They provide warmth during resuscitation and for any subsequent invasive procedures. It is important to keep in mind that this source of heat does not protect the infant from evaporative heat loss but, instead, encourages evaporative heat losses.
  • 9. Keep Warm ā€¢ Continuous monitoring of temperature should occur as soon as possible after the delivery. Premature infants (< 1500 g) should be covered in plastic wrap (polyethylene) to prevent excessive heat loss. A full resuscitation, including line placement, can and should be performed with the plastic wrap in place. A woolen head cap should be used.
  • 10. Keep Warm ā€¢ Another common source of heat loss in the neonate undergoing resuscitation is the use of unheated non-humidified oxygen sources for the bag-valve-mask device. The inspired gases sent to the lungs are subsequently heated and humidified by the infant; this results in massive heat exchange from evaporative heat loss and insensible water loss. Whenever possible, warmed and humidified gases should be provided in the resuscitation area.
  • 11. Airway management ā€¢ Once in a heated environment, the infant should be positioned so as to open the airway, and the mouth and nose should be suctioned. ā€¢ Should suction involve larynx and Trachea?
  • 12. Easy answer is no!! ā€¢ Infants have a vagal reflex response to sensory stimulation of the larynx, which may induce apnea, bradycardia, hypotension, and laryngospasm. ā€¢ Suctioning the posterior oral airway or the trachea with a catheter because of extremely thick or meconium-stained fluids may cause profound central apnea, potentially profound bradycardia, and laryngospasm
  • 13. Suctioning ā€¢ Instillation of saline into the trachea also has been shown to stimulate the afferent sensory neurons leading to apnea, bradycardia, hypotension, and laryngospasm. ā€¢ Suctioning the posterior oral airway or the trachea consequently has no place in the immediate resuscitation period. ā€¢ Lung inflation has been shown to reverse the effects of vagal stimulation.
  • 14. Code Pink If called to Delivery suite Heart Rate is the critical sign. >100 is crucial
  • 15. Bradycardia is Bad ā€¢ Normal Newborn HR is 100-160 ā€¢ HR below 100 requires Positive Pressure Ventilation and Pulse Oximetry ā€¢ This is irrespective of normal or abnormal Respiratory effort
  • 16. Why is Bradycardia bad? ā€¢ A fetus or newborn that is subjected to asphyxia initiates a "diving" reflex in an attempt to maintain perfusion and oxygen delivery to vital organs. Hypoxia and acidosis lead to pulmonary arteriolar vasoconstriction. Pulmonary vascular resistance increases, leading to decreased pulmonary blood flow and increased blood flow directly to the left atrium.
  • 17. Why is Bradycardia bad? ā€¢ Systemic cardiac output is redistributed, with increased flow to the heart, brain, and adrenal glands and decreased flow to the rest of the body. Early in the course of asphyxia, systemic blood pressure increases. ā€¢ With ongoing hypoxia and acidosis, however, the myocardium fails and bradycardia occurs; this causes a decrease in blood pressure and tissue perfusion, leading to eventual tissue ischemia and hypoxia.
  • 18. ā€¢ With prolonged asphyxial insult and failure of compensatory mechanisms, cerebral blood flow falls, leading to ischemic brain injury
  • 19. What about Oximetry? ā€¢Is a cyanosed Newborn normal?
  • 20. Targeted pre-ductal SpO2 after birth ā€¢ 1min 60-70% ā€¢ 2min 65-85% ā€¢ 3min 70-90% ā€¢ 4min 75-90% ā€¢ 5min 80-90% ā€¢ 10min 85-90%
  • 21. Changes in circulation after birth
  • 22. Reversal of right to left shunting ā€¢ Clamping of the umbilical cord removes the low-resistance placental vascular circuit and thereby raises total systemic vascular resistance, with a resultant increase in left ventricular and aortic pressures. The increased systemic vascular resistance, combined with the decreased pulmonary vascular resistance, reverses the shunt through the ductus arteriosus (from right-to-left shunting to left-to- right shunting) until the ductus closes completely. ā€¢ All of these events result in closure of the other fetal shunts. With the decrease in right atrial pressure and the increase in left atrial pressure, the 1-way "flap-valve" foramen ovale is pushed closed against the atrial septum. This functional closure at birth is followed by anatomic closure, which usually occurs at several months of age.
  • 23. ā€¢ Functional closure of the ductus arteriosus generally occurs within 72 hours of life, with anatomic closure by age 1-2 weeks. ā€¢ Functional postnatal circulation generally is established within 60 seconds; however, completion of the transformation can take up to 6 weeks.
  • 24. How to correct Bradycardia ā€¢ PPV using Neopuff ā€¢ 5cm PEEP (Positive End Expiratory Pressure) ā€¢ 30cm PIP (Peak Inspiratory pressure) ā€¢ Settings should already be made on resus trolley
  • 25. PPV ā€¢ Ventilatory rates of 40-60 breaths/min should be provided initially, with proportionally fewer assisted breaths provided if the infant's spontaneous respiratory efforts increase.
  • 28. What to do if HR< 60 ā€¢ Commence Chest compressions ā€¢ 100% O2 ā€¢ Intubation or LMA
  • 29. HR< 60 Chest compressions should be initiated after only 30 seconds of effective PPV if the heart rate remains below 60 beats/min.
  • 31. Chest Compressions ā€¢ Pressure should be applied to the lower portion of the sternum, depressing it to a depth of about one third of the anterior-posterior diameter. The chest should fully re-expand during relaxation. One ventilation should be interposed after every 3 chest compressions. ā€¢ An overall rate of 120 compression/ventilation events per minute is recommended; with the 3:1 compression-to-ventilation ratio, this equates to 90 compressions and 30 breaths each minute.
  • 32. Chest Compressions ā€¢ Evaluate heart rate and color every 30 seconds. Infants who fail to respond may not be receiving effective ventilatory support; thus, constantly evaluating ventilation is imperative. Chest compressions should be discontinued when the heart rate is 60 beats/min or higher.
  • 33. Intubation ā€¢ If things still not going well then intubation required
  • 34. Intubation Blade size 0 or 1 should be chosen in accordance with the size of the infant. Premature infants may be more easily intubated with a size 0 blade, and term infants require a size 1 blade. Endotracheal tube should be chosen in accordance with the weight of the infant . ā€¢ Table 3. Endotracheal Tube Size and Measurement at Lip According to Infant Weight ā€¢ Infant Weight Endotracheal Tube Size Endotracheal Tube Measurement at Lip ā€¢ < 1000 g 2.5 7 cm ā€¢ 1000-2000 g 2.5-3 8 cm ā€¢ 2000-3000 g 3-3.5 9 cm ā€¢ > 3000 g 3.5-4 10 cm
  • 35. Intubation ā€¢ Another way of estimating correct placement of the ET tube is to take the weight of the infant in kilograms and add 6 to yield the number of centimeters at which the tube should be secured at the lip.
  • 36. Intubation ā€¢ Assessment for equal bilateral breath sounds with maintenance of oxygenation. ā€¢ An increase in the heart rate within 5-15 seconds is an excellent indicator of adequate ventilation and appropriate ET tube placement.
  • 37. Intravenous Access ā€¢ Needed for Volume expansion ā€¢ Administration of Adrenaline
  • 38. Intravenous Access ā€¢ Peripheral Venous access ā€¢ Umbilical Vein Catheterisation ā€¢ Intraosseous access generally not recommended (Too small intramedullary space and fragile bones)
  • 39. Intravenous Access ā€¢ Umbilical vein catheterization may be a life- saving procedure in neonates who require vascular access and resuscitation. ā€¢ The umbilical vein remains patent and viable for cannulation until approximately 1 week after birth
  • 41. Umbilical Vein Catheterisation ā€¢ Advance the catheter only 1-2 cm beyond the point at which good blood return is obtained. This is approximately 4-5 cm in a full-term neonate.
  • 42. Umbilical Vein Catheterisation ā€¢ Secure the catheter with a suture through the cord, marker tape, and a tape bridge. ā€¢ The position of the catheter must be confirmed radiographically. A properly placed umbilical vein catheter appears to travel cephalad until it passes through the ductus venosus
  • 43. Adrenaline ā€¢ The recommended dose is 0.01-0.03 mg/kg (0.1-0.3 mL of the 1:10,000 solution), preferably administered intravenously (IV). Higher IV doses are not recommended
  • 44. Adrenaline ā€¢ If you are too overwhelmed and canā€™t think ā€¢ Easy tip to remember is that average newborn in size will need 1ml of 1:10,000 Adrenaline
  • 45. Adrenaline ā€¢ If vascular access cannot be obtained, Adrenaline may be given via the ET tube ā€¢ The dose should be increased to 3 times the IV dose. Followed with infusion of 0.5-1 mL of saline to ensure that the drug is delivered to the lung, where it is absorbed and delivered to the heart.
  • 46. Volume Expansion ā€¢ Suspected Blood loss ā€¢ Pale poor perfusion or weak pulse ā€¢ Not responded to other resuscitative measures 10ml/kg IV push over few minutes
  • 47. Anything else? ā€¢ ā€œDEFGā€ Donā€™t ever forget Glucose If glucose low, administer 5ml/kg 10% Dextrose and recheck
  • 48. What Next? ā€¢Get as much help as possible locally ā€¢NETS retrieval to NICU

Editor's Notes

  1. Refer to handout Newborn Life support
  2. We normally donā€™t think too much about this. Very important in neonates.
  3. Hopefully we are not called to premature resus
  4. This is the over riding goal, and resus is aimed at this. Keep this figure in mind. All following measures aim for this goal
  5. Bradycardia sign of asphyxia and hypoxia
  6. Thatā€™s why bradycardia is a very bad sign
  7. Colour of newborn poor indicator of status
  8. Brief overview of Foetal and newborn CVS
  9. Refer to guide