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Synthetic red blood cells and platelets

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Synthetic red blood cells and platelets

  1. 1. <ul><li>Synthetic Red Blood Cells are created from spare IVF embryos . </li></ul><ul><li>Since the blood is synthetic it would not be at risk to carry viruses such as HIV and Hepatitis. </li></ul><ul><li>The military and trauma surgeons always need a fresh supply of blood and the synthetic blood would replicate the universal donor blood. </li></ul>
  2. 3. <ul><li>Creating synthetic red blood cells requires spare multipotent stem cells from IVF embryos. </li></ul><ul><li>Although beneficial, the procedure raises ethical issues since it is the destruction of an embryo, which is potential human life. </li></ul>
  3. 5. <ul><li>The master template (grey) is fabricated using advanced lithographic techniques. A unique liquid fluoropolymer (green) is poured on the surface of the master template and photochemically cross linked (top row, left), then peeled away to generate a precise mold having micro- or nanoscale cavities ( upper middle). The unique properties of the PRINT mold enable a liquid substance (red) to fill the  cavities  (top row, right) through capillary filling. Once the liquid in the mold cavities is converted to a solid, the array of particles (red) can be removed (bottom row, middle) from the mold (green) by bringing the mold in contact with a harvesting film (yellow) that enables the particles to be easily handled, chemically modified, and analyzed. At this point free flowing particles or stable dispersions can be obtained by separating the harvesting film from the particles (bottom row, left). </li></ul>
  4. 6. <ul><li>Similar to synthetic red blood cells in that they are derived from stimulated human embryonic stem cells. </li></ul><ul><li>The stem cells are turned into platelet-producing cells, called megakaryocytes. </li></ul>
  5. 8. <ul><li>The use of stem cell derived platelets has increased in the field of Regenerative Medicine. </li></ul><ul><li>Orthopedic injuries seen in athletes such as torn ligaments and tendonitis can be treated with a combination of stem cell and platelet rich plasma injection therapy or PRP therapy. </li></ul><ul><li>The process begins with an injection of stem cells in a localized area of the injury and then finally an injection of the platelet rich plasma. </li></ul>

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