CHIẾN LƯỢC PHỐI HỢP THUỐC HIỆU QUẢ, VAI TRÒ NỀN TẢNG CỦA ƯCMC TRONG BẢO VỆ TIM MẠCH

1. GS. TS. VÕ THÀNH NHÂN
ĐH Y Dược – BV Chợ Rẫy TPHCM

3. Hypertension World Prevalence
Diagnosis % of Diagnosed BP Controlled
Millions
2000 2025

4. Intermediate “Aiming” Targets

6. Cerebral
Infarction
Myocardial
Infarction
Sudden
Death
Stable
Angina
Protecting the Patient from Cardiovascular Events

7. factor). This imbalance contributes to progression of hypertension and associated cardiovascular risk.
In the newly diagnosed individual with hypertension, whether young or old, the vascular

12. controlled trial. LANCET Volume: 366 Issue: 9489 Pages: 895-906 Published: SEP 10 2005.

13. Endothelium
Endothelium
Tunic
Intima
Lipid
Macrophages
Neointima
Protecting the Endothelium & Intima

14. AT2
AT1
Apoptosis
Endothelial
Disruption
Protecting the Endothelium & Intima

15. AT2
AT1
Apoptosis
Endothelial
Continuity
Protecting the Endothelium & Intima

16. Physiological Effects of Bradykinin

17. Pertinent Sub-study
Perindopril Increases Bradykinin
Concentration

18. Effective Treatment of Coronary Artery Disease
Fox KM et al EUROPA Trial Lancet. 2003 Sep 6;362(9386):782-8.

19. Collagen
Fibres
Prevention of Vascular Changes in Hypertension

20. Change in
Mean Brachial
Blood Pressure
(mmHg)
Effective Treatment of Hypertension

21. Brachial SBP Central SBP
Brain
Heart
Kidney
Arm
Effective Treatment of Hypertension
Williams B et al. CAFÉ Study Circulation 2006; 113:1213-25.

22. Effective Treatment of Hypertension
Dahlof B et al. ASCOT-BPLA Study Lancet 2005; 46:895-906.

23. Which combination?

25. Which combination is the best?

26. Vs.
“Which combination is best ?”

27. Winning Combinations

28. Losing Combinations
Never played e.g.

29. “Which combination is best ?”

30. EURO 2016– Man of the Match / Golden Ball

31. ADVANCE trial- CCB Analysis

32. ADHERENCE --------> BP LOWERING ----> CARDIOVASCULAR PROTECTION