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URINARY
TRACT
INFECTION
(UTI)
It is the bacterial invasion of the urinary
tract system
INCIDENCE
• Per year 25,0000 cases are reported
• More in women
• After 65 greater risk for Pyelonephritis in men
due to prostatitis.
TYPES
• UPPPER UTI Acute Pyelonephritis
• LOWER UTI Urethritis
Cystitis
Prostatitis
FACTORS CONTRIBUTING FOR UTI
Obstruction
Microorganisms
Calculi
Vesicoureteral reflux
Diabetes Mellitus
Characteristics of Urine
Gender
Age
Sexual activity
Recent use of antibiotics
PYELONEPHRITIS
• It is the bacterial infection and inflammation
of the kidney and renal pelvis.
TYPES
• ACUTE PYELONEPHRITIS
• CHRONICPYELONEPHRITIS
ACUTE PYELONEPHRITIS
• It is the active bacterial infection
• It involves acute tissue inflammation, tubular
cell necrosis and abscess formation, which are
pockets of infection with pus can occur
anywhere within the kidney.
CAUSES
Bacterial invasion
Pregnancy
Obstruction
Reflux
CHRONIC PYELONEPHRITIS
• It results from repeated or continuous urinary
tract defect, obstruction or commonly when
urine refluxes from the bladder back into the
ureters.
CAUSES
Any structural deformity
PATHOPHYSIOLOGY
Microbial invasion of Renal Pelvis
Inflammatory response
Fibrosis or scar tissue formation
Decreased tubular reabsorption & secretion
Impaired renal function
DIAGNOSTIC EVALUATION
History collection
Physical examination
Psychosocial examination
Laboratory examination
Urinalysis
Presence of WBC, Bacteria, RBC and protein
ESR
Imaging examination
X- kidney
KUB
IV Urography
SIGNS & SYMPTOMS
ACUTE PYELONEPHRITIS
o Fever
o Chills
o Tachycardia
o Tachypnea
o Flank, back or loin pain
o Tender CVA
o Abdomen, often colicky & discomfort
o Nausea & vomiting
o General malaise & fatigue
o Burning, urgency or frequency of urination
o Nocturia
CHRONIC PYELONEPHRITIS
o Hypertension
o Inability to conserve sodium
o Nocturia
o Hyperkalemia
o Acidosis
• MANAGEMENT
NON SURGICAL
i. DRUG THERAPY
ii. NUTRITIONAL THERAPY
iii. FLUID THERAPY
iv. HEALTH EDUCATION
DRUG THERAPY
1. BROAD SPECTRUM ANTIBIOTICS
• Gentamicin
250 – 500 mg/day
It has both bactriostatic & bacteriocidal action.
Also act against gram +ve and gram –ve
organisms.
2. URINARY ANTISEPTICS
• NITROFURANTOIN
100 mg every 12 hour.
It has bacteriostatic action
SURGICAL MANAGEMENT
PYELOLITHOTOMY
Stone removal from the kidney
NEPHRECTOMY
Removal of the kidney
URETROPLASTY
Ureter revision or repair
CYSTITIS
• It is the inflammation of the urinary bladder
• It if the most common among UTI
INCIDENCE
• It is the second most condition after RTI
• The incidence of symptoms is more than 5
million per year
• About half of them are reported and
diagnosed as UTI.
TYPES
A. INFECTIOUS
B. NON INFECTIOUS
C. INTERSTITIAL
INFECTIOUS
• It is caused by microorganisms. Escherichia
coli (E. coli)
NON INFECTIOUS
• It is caused from chemical exposure such as
Drugs {chemotherapy drugs
cyclophosphamide and ifosfamide}, radiation
therapy and auto immune disorders.
INTERSTITIAL
• It is a rare and chronic inflammation of the
entire urinary tract ( bladder, urethra &
adjacent pelvic muscles).
• It is not a result of infection {diabetes, kidney
stones, an enlarged prostate or spinal cord
injuries}
• it occurs 10 times more in women than men.
• Features are intense urgency & bladder pain.
CAUSES
Infection
Bacteria
Virus {Cytomegalovirus}
Fungus {Candida }
Parasites {schistosomiasis}
Irritation of Urethra
Catheterization
Trauma
PATHOPHYSIOLOGY
Bacteria from out side the body enters into the urinary
tract due to any procedure or irritation of the urethra
Urosepsis occurs
Organ failure
Sepsis
Death
CLINICAL FEATURES
COMMON
 Frequency
 Urgency
 Dysuria
 Hesitancy
 Nocturia
 Low back pain
 Incontinence
 Pyuria
 Hematuria
 Retention
 Suprapubic tenderness or fullness
 Felling of incomplete bladder emptying.
 Cloudy, foul smelling blood tinged urine
RARE CLINICAL FEATURES
Fever
Chills
Nausea & vomiting
Malaise
Flank pain
DIAGNOSTIC STUDIES
History collection
Physical examination
Laboratory examinations
Pyuria
Hematuria
Imaging studies
IV Urography
Abdominal sonography
CT
Cystoscopy
Retrograde pyelography
IV Urography
Abdominal sonography
Cystoscope
Rigid Cystoscope
Flexible Cystoscope
Retrograde pyelography
MANAGEMENT
MEDICAL
MANAGEMENT
1) ANTI MICROBIALS
A) QUINOLONES
• Ciprofloxacin
250 mg orally twice daily
It has bacteriostatic and bactericidal action
B) PENICILLINS
• AMOXICILLIN
500 mg orally every 12 hour.
it has bactericidal action
C) CEPHALOSPORINS
• CEFADROXIL
1 gm orally every 12 hour
it has bactericidal action
2) URINARY ANTISEPTICS
• NITROFURANTOIN
100 mg every 12 hour.
It has bacteriostatic action
3) BLADDER ANALGESICS
• PHENAZOPYRIDINE
200 mg orally 3 times daily after meals
It reduces bladder pain and burning by exerting a
topical analgesic or local anesthetic effect on
the bladder mucosa.
4) ANTISPASMODICS
• HYOSCYAMINE
0.125 – 0.25 mg orally, 3 to 4 times daily.
It relieves bladder spasms by inhibiting
nerve stimulation to the bladder muscle.
URETHRITIS
It is the infection & inflammation of the urethra.
CAUSES
• IN MEN
STD
• IN WOMEN
Low estrogen level.
CLINICAL FEATURES
• Painful or difficulty urination
• Discharge from penis or vagina
• Discomfort in lower abdomen
• Pyuria
MANAGEMENT
• Estrogen vaginal cream in women
It increases the amount of estrogen in the
vagina thereby reduces the irritation
PROSTATITIS
• It is the inflammation of the prostate gland.
ETIOLOGY
Bacterial infection
Escherichia coli, Enterobacter, Pseudomonas
STD { chlamydia and gonorrhea}
Auto immune disorders
Neuromuscular causes
Primary vesical neck obstruction, pseudodyssynergia
(failure of the external sphincter to relax during
voiding), impaired detrusor contractility, or
acontractile detrusor muscle
Allergy mediated reactions
Psycho sexual problems (Pelvic floor tension}
TYPES
4 types
ACUTE BACTERIAL
CHRONIC BACTERIAL
NON BACTERIAL/ CHRONIC PELVIC PAIN
SYNDROME
ASYMPTOMATIC INFLAMMATORY PROSTATITIS
ACUTE BACTERIAL
It may occurs with Urethritis or an infection of
the lower urinary tract.
Organism may reach the prostate via blood
stream or the urethra.
CLINICAL FETAURES
Fever
Chills
Dysuria
Urethral discharge
Boggy tender prostate
CHRONIC BACTERIAL
• Chronic bacterial prostatitis is a rare condition
that causes recurring infections in the prostate
and results in swelling, inflammation, and
frequent urinary tract infections (UTIs).
• It may occur in older men
Diagnostic studies
PSA
• 4.0 ng/mL
CLINICAL FETAURES
Hesitancy
Urgency
Dysuria
Difficulty initiating and terminating the flow of
urine
Decreased strength and volume of urine.
Discomfort in perineum, scrotum and penis.
Irregularly enlarged prostate, firm and slightly
tender when palpate
MANAGEMENT
Sitz bath
Stool softeners
NSAIDS
Alpha blockers
a) Stool softeners
To prevent straining and rectal irritation of the
prostate during a bowel movement
b) Alpha Blockers
Tamsulosin
0.4 mg/ day
It constricts the prostate gland, thereby
reduce urethral pressure and improving urine
flow.
c) Sitz Bath
• It reduces prostatic irritation.
d) Muscle relaxants
• HYOSCYAMINE
0.125 – 0.25 mg orally, 3 to 4 times daily.
It relieves bladder spasms by inhibiting
nerve stimulation to the bladder muscle
NON BACTERIAL/ CHRONIC
PELVIC PAIN SYNDROME
Pelvic or perineal pain without evidence of
urinary tract infection, lasting longer than 3
months
Pain may radiate to the back and rectum, making
sitting uncomfortable. Pain can be present in the
perineum, testicles, tip of penis, pubic or bladder
area.
Dysuria, arthralgia, myalgia, unexplained fatigue,
abdominal pain, constant burning pain in the
penis, and frequency may all be present
ASYMPTOMATIC
INFLAMMATORY PROSTATITIS
 Asymptomatic inflammatory prostatitis is a
painless inflammation of the prostate gland
where there is no evidence of infection.
It is a common finding in men with BPH.
HEALTH EDUCATION
 Instruct to avoid alcohol, coffee, tea and spicy
foods that irritate symptoms.
 Instruct to avoid decongestants and
antihistamines that may irritate.
 Explain the importance of antibiotic therapy
and fluid management.
Urinary Tract  infection

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