2. Short stature
ā¢ Height < 3rd centile for chronological age of patient
Proportionate
Disproportionate Short trunk
Short limbed Rhizomelic (proxima)
Mesomelic (middle)
Acromelic (distal)
TONY SCARIA 2010 KMC
8. Intrinsic disturbance of
formation growth
remodelling of bone &
cartilage d/t genetic &
inborn biochemical
errors
Achondroplasia
Hypochondroplasia
TONY SCARIA 2010 KMC
9. Achondroplasia
ā¢ MC of Rhizomelic dwarfism
ā¢ MC form of skeletal dysplasia
ā¢ Risk increases with increasing paternal age
ā¢ AD
ā¢ Spontaneous mutation in 80 %
TONY SCARIA 2010 KMC
10. Achondroplasia
ā¢ Defect in endochondral ossification of bones
ā¢ Membranous & periosteal ossification are undisturbed
TONY SCARIA 2010 KMC
11. AD condition with FGFR3 affection in
achondroplasia
TONY SCARIA 2010 KMC
13. CF of achondroplasia
ā¢ Disproportionate dwarfism
ā¢ Short limb out of proportion to trunk
ā¢ Trident hand
ā¢ Flexion contracture elbow
ā¢ Radial head subluxation
ā¢ Skull is large with bulging vault & forehead
ā¢ Intelligence & sexual development is normal
ā¢ Joints & cartilage are normal
ā¢ Dorsolumbar kyphosis increased lumbar lordosis
ā¢ Lumbar stenosis
TONY SCARIA 2010 KMC
16. Trident hand sign in achondroplasia
A trident hand is a description where the hands are short with
stubby fingers, with a separation between the middle and ring
fingers.
TONY SCARIA 2010 KMC
31. Apex vertebrae
Modt rotated vertebrae in the curve & most deviated
vertebrae from central vertical axis
TONY SCARIA 2010 KMC
32. Kyphoscoliosis Scoliosis + increased kyphosis (normal kyphosis in
thoracic spine is 20-40*)
Lordoscoliosis Scoliosis +decreased kyphosis (<20*)
TONY SCARIA 2010 KMC
33. Functional scoliosis Structural scoliosis
Curve with no structural component & corrects on
side bending x rays
A segment of spine with fixed alteral curve & donot
correct on side bending x rays
TONY SCARIA 2010 KMC
43. Pseudofractures in osteomalacia
ā¢ b/l symmetrical
ā¢ Perpendicular to cortex
ā¢ MC sites
ā¢ Femoral neck
ā¢ Medial femoral cortex
ā¢ Ischiopubic ramus
ā¢ Axillary border of scapula
ā¢ Proximal ulna
ā¢ Distal ulna
ā¢ Absent callus
ā¢ Mild sclerosis
TONY SCARIA 2010 KMC
44. Rickets
ā¢ Generalised osteopenia
ā¢ Widened growth plate (earliest specific x ray sign)
ā¢ Cupping splaying & fraying of metaphysis (paint brush metaphysis)
ā¢ Absent zone of provisional calcification (earliest sign on x ray)
ā¢ Bow shaped legs
ā¢ Pigeon shaped chest
ā¢ Rachitic rosary
ā¢ Craniotabes
ā¢ Protrusio acetabuli & triradiate pelvis
ā¢ Reappearance of dense white zone of provisional calcification is the first sign of healing
rickets
ā¢ Windswept deformity
TONY SCARIA 2010 KMC
48. Scurvy
ā¢ Generalised osteopenia
ā¢ Dense white line of provisional
calcification (white line of frenkel)
ā¢ Ring epiphysis (wimberger sign)
ā¢ Pelkan spurs
ā¢ Corner or angle sign (irregular
metaphyseal corner)
ā¢ Trummerfield zone (scorbutic zone)
ā¢ Area of radlucency above whiteline
ā¢ Subperiosteal haemorrhage
All signs of scurvy disappear except white
line of frenkel
TONY SCARIA 2010 KMC
49. Subperiosteal hemorrhage
ā¢ in distal femur and tibia and proximal humerus,
ā¢ causing excruciating tenderness pain near the large joints.
ā¢ The child lies still to minimize pain or minimally move the affected
limb (pseudoparalysis) - (Frogs like posture is attained by child)
TONY SCARIA 2010 KMC
56. ā¢ periosteal reaction due to subperiosteal haemorrhage
ā¢ haemarthrosis
ā¢ Wimberger's ring sign:
ā¢ circular, opaque radiologic shadow surrounding epiphyseal centers of ossification,
which may result from bleeding
ā¢ Frankel's line:
ā¢ dense zone of provisional calcification
ā¢ TrĆ¼mmerfeld zone:
ā¢ lucent metaphyseal band underlying Frankel's line
ā¢ Pelken spur: metaphyseal spurs which result in cupping of the metaphysi
TONY SCARIA 2010 KMC
57. ā¢ scorbutic rosary:
ā¢ expansion of the costochondral junctions
ā¢ may relate to fracturing of the zone of provisional calcification during normal
respiration
ā¢ In RicketsāRosary is Round and non-tender, and in Scurvy it is Sharp and
tender
TONY SCARIA 2010 KMC
63. Erlenmayer flask deformity is also seen in
osteopetrosis
ā¢ Also seen in
ā¢ Thalassemia
ā¢ Sickle cell anemia
ā¢ Pyleās disease
(Craniometaphyseal
deformity )
ā¢ Diaphyseal aclasis
ā¢ Osteodysplasty
ā¢ Gaucherās
ā¢ Nieman pick disease
TONY SCARIA 2010 KMC
67. Primary hyperparathyroidism Secondary hyperparathyroidism Tertiary hyperparathyroidism
Skeletal features only Renal osteodystrophy ļ skeletal
features
Skeletal changes less florid More florid
Sclerosis rare Common
Brown tumour ļ common less common
Chondrocalcinosis common Less common
Soft tissue & vascular calcification
less common
More common
TONY SCARIA 2010 KMC
68. Radiological features of primary
hyperparathyroidism
ā¢ Subperiosteal resorption of phalanges
ā¢ Irregular diffuse rarefaction of bone
ā¢ Salt & pepper appearance of skull
ā¢ Multiple cyst in pelvis & other bones
ā¢ Brown tumour
TONY SCARIA 2010 KMC
69. Subperiosteal resorption of bone ā¢ Earliest & best seen at radial aspect of middle
phalanges of middle & index finger
ā¢ Other sites are lamina dura of teeth / superior &
inferior margins of ribs ,medial aspects of proximal
humerus & tibia
Trabecular bone resorption ā¢ Salt and pepper skull
ā¢ Loss of definition of outer table & inner table
Other bone resorption ā¢ intracortical / endosteal/ subphyseal /
subligamentous
Brown tumour ā¢ Represent repeated haemorrhages with in bone
ā¢ Lytic expansile lesion
ā¢ Mc site ļ mandible (mc)/ clavicle /ribs/ tubular
bones
Chondrocalcinosis ā¢ Calcification of hyaline / fibrocartilage
ā¢ CPPD deposition
ā¢ Knee (mc) aslo affect symphysis pubis ,trainaglar
cartilage of wrsit
TONY SCARIA 2010 KMC
70. Subperiosteal resorption of phalanges in
primary hyperaparathyroidism
ā¢ Earliest & best seen at
radial aspect of middle
phalanges of middle &
index finger
TONY SCARIA 2010 KMC
71. ā¢ X-ray findings of
hyperparathyroidism:
ā¢ Subperiosteal resorption of the
terminal phalanx
ā¢ Pathognomonic
TONY SCARIA 2010 KMC
72. Salt and pepper skull appearance
ā¢ hyperparathyroidism.
ā¢ It occurs due to resorption of
the trabecular bone in the
skull and replacement of the
reabsorbed bone by a newly
formed connective tissue
causing loss of integrity in the
shape of skull bones
TONY SCARIA 2010 KMC
73. Salt & pepper appearance of skull in primary
hyperaparathyroidism
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74. Loss of lamina dura in primary
hyperaparathyroidism
TONY SCARIA 2010 KMC
75. Multiple cyst in pelvis & other bones in
primary hyperaparathyroidism
TONY SCARIA 2010 KMC
76. Brown tumour/ osteitis fibrosa cystica
/vonrecklinghausen disease of bone
ā¢ Represent repeated haemorrhages with in bone
ā¢ Lytic expansile lesion
ā¢ Mc site ļ mandible (mc)/ clavicle /ribs/ tubular bones
TONY SCARIA 2010 KMC
78. Brown tumour in hyperparathyroidism
ā¢ a. Brown tumors are tumors of bone that arise in
settings of excess osteoclast activity, such as
hyperparathyroidism, and consist of fibrous tissue,
woven bone and supporting vasculature, but no
matrix.
ā¢ b. They are radiolucent on x-ray. The osteoclasts
consume the trabecular bone that osteoblasts lay
down and this front of reparative bone deposition
followed by addition resorption can expand beyond
the usual shape of the bone, involving the
periosteum and causing bone pain.
ā¢ c. The characteristic brown coloration results from
hemosiderin deposition into the osteolytic cysts. Also
characteristic of giant cell tumors of the bone.
TONY SCARIA 2010 KMC
79. Chondrocalcinosis
ā¢ Calcification of hyaline /
fibrocartilage
ā¢ CPPD deposition
ā¢ Knee (mc) aslo affect symphysis
pubis ,trainaglar cartilage of wrsit
TONY SCARIA 2010 KMC
80. ā¢ Rugger jersey spine
ā¢ Patients with renal
failure with 2* HPT
ā¢ Combination of
osteomalcia
osteosclerosis & 2*
Hyperparathyroidism
ā¢ Renal osteo dystrophy
TONY SCARIA 2010 KMC
91. Eosinophilic granuloma
ā¢ Lytic lesion in skull & lytic bones
ā¢ Skull ļ 50 % (mc site in children) followed by spine
ā¢ Pelvis ļ 23%
ā¢ Femur -->17 %
ā¢ Ribs ļ 8 %most common site in adult
TONY SCARIA 2010 KMC
92. Manifestations of eosinophilic granuloma
Skull Mandible Spine Long bones
ā¢ Solitary lytic punched
out lesions
ā¢ Hole with in whole
ā¢ Bevelled edges
ā¢ Geographical skull
ā¢ Button sequestrate
ā¢ Erosison of almina
duraļ flating tooth
appearance
Vertebra plana Permeative & aggressive
appearing lesions
TONY SCARIA 2010 KMC
97. Type I (hurler syndrome) Type IV (morquio syndrome)
ā¢ Macrocephaly with narrowed skull base
ā¢ J shaped sella tursica
ā¢ Pointed proximal ends of metcarpals
ā¢ Anteroinferior beaking of vertebral bodies
ā¢ Normal height of vertebra
ā¢ Oar / paddle like ribs(expended anterior ends of
ribs)
ā¢ Macrocephaly with narrowed skull base
ā¢ J shaped sella tursica
ā¢ Pointed proximal ends of metcarpals
ā¢ Central tongue like beaking of vertebral bodies
ā¢ Platysondyly ļ decreased height of vertebrae
TONY SCARIA 2010 KMC
98. Hurler syndrome
J shaped sella
Pointed metacarpal
Broadened anterior end of ribs ļ oar shaped
TONY SCARIA 2010 KMC
106. Type I Type II Type III Type Iv
Inheritance AD AR AD/ AR AD
Most common Most lethal
Blue sclera Blue sclera Blue sclera Normal
TONY SCARIA 2010 KMC
108. Radiological features of OI
ā¢ Diffuse decrease in bone density
ā¢ Multiple diphyseal #with excessive callus formation (in battered baby syndrome ļ multiple metaphyseal #)
ā¢ Bowed deformed bones
ā¢ Skull ļ wormian bones
TONY SCARIA 2010 KMC
121. Psoriatic arthritis
ā¢ Mc joint in hands ļ DIP
ā¢ Asymmetrical
ā¢ Soft tissue swelling
ā¢ Normal bone density
ā¢ Widened joint space
ā¢ Marginal articular erosions (mouse ear erosions)
ā¢ Pencil in cup deformity
TONY SCARIA 2010 KMC
128. AS
ā¢ b/l symmetrical sacroilitis
ā¢ In lower 2/3rd of joint
ā¢ Iliac side more involved (initially)
ā¢ Earliest change can be detected by MRI
ā¢ Best investigation is CEMRI
TONY SCARIA 2010 KMC
129. Enthesitis ļ inflammation @ site of insertion of
ligament
ā¢ Romanas sign
ā¢ Shiny corner sign
ā¢ Squaring of vertebra ļ bamboo spine
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130. Romanas sign
ā¢ d/t inflammation at site of
insertion of ligament
TONY SCARIA 2010 KMC
141. Neuropathic arthropathy
Atrophic type Hypertrophic type
Licked candy stick appearance 6 D
ā¢ Distension of joint
ā¢ Destruction
ā¢ Debris
ā¢ Dislocation
ā¢ Deformity
ā¢ Density of bone increased
TONY SCARIA 2010 KMC
145. Melorheostosis:
ā¢ Melorheostosis (Greek, āflowing hyperostosisā) may occur
sporadically or follow a pattern consistent with an autosomal
recessive disorder.
ā¢ The major manifestation is progressive linear hyperostosis in one or
more bones of one limb, usually a lower extremity.
ā¢ The name comes from the radiographic appearance of the involved bone,
which resembles melted wax that has dripped down a candle.
TONY SCARIA 2010 KMC
146. ā¢ Symptoms appear during childhood as pain or stiffness in the area of sclerotic bone.
ā¢ There may be associated ectopic soft tissue masses, composed of cartilage or osseous tissue, and
skin changes overlying the involved bone, consisting of scleroderma-like areas and hypertrichosis.
ā¢ The disease does not progress in adults, but pain and stiffness may persist.
ā¢ ā Laboratory tests are unremarkable.
ā¢ ā No specific etiology is known.
ā¢ ā There is no specific treatment.
ā¢ ā Surgical interventions to correct contractures are often unsuccessful.
TONY SCARIA 2010 KMC
148. Radiological features of osteoporosis
ā¢ X ray:
ā¢ poor test for osteoporosis. Its evident on x ray only when 30% of bone
loss is there. cod fish mouth vertebra. Singh and Maini index is the
index used for osteoporosis based on x ray of hip joint.
TONY SCARIA 2010 KMC
149. Singh and Maini index is the index used for
osteoporosis based on x ray of hip joint
TONY SCARIA 2010 KMC
153. ā¢ Dexa scan:
ā¢ Investigation of choice.
ā¢ Gold standard for diagnosis
ā¢ Dual energy absorption scan
ā¢ Value is given as T-score (most commonly used, compares BMD with 25 year
male, lumbar spine BMD) or Z score (age and sex matched)
TONY SCARIA 2010 KMC
154. Dual energy X-ray absorptiometry (DEXA)
ā¢ gold standard for the diagnosis of osteoporosis
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159. For assessment of osteoporosis
ā¢ Three sites choosen:
ā¢ Hip, spine, wrist.
ā¢ Value of one site only give bone mineral density (BMD) and
prediction fracture of that site only
TONY SCARIA 2010 KMC
168. ā¢ Fluorine stimulates osteoblastic activity; fluoroapatite crystals are
laid down in bone and these are usually resistant to osteoclastic
resorption. This causes calcium retention implied mineralization and
secondary hyperparathyroidism.
TONY SCARIA 2010 KMC
193. Wimbergers sign
ā¢ bilateral focal destruction of the medial
aspect, proximal tibial metaphyses;
ā¢ pathognomonic for congenital syphilis
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194. ā¢ Wimberger's Ring Sign-
ā¢ denser white line of calcification
encircling the osteoporotic
epiphyses
ā¢ in scurvy
TONY SCARIA 2010 KMC
195. Celery stalk metaphysis
ā¢ Celery stalk metaphysis refers to a
plain film appearance of the
metaphyses in a number of conditions
characterised by longitudinally aligned
linear bands of sclerosis. They are seen
in:
ā¢ congenital infections
ā¢ congenital rubella
ā¢ congenital syphilis
ā¢ congenital cytomegalovirus (CMV)
TONY SCARIA 2010 KMC
199. Simple bone cyst/ solitary/ unicameral
ā¢ Before the age of 20 years
ā¢ Mc site is proximal humerus followed by proximal femur
ā¢ Expansile
ā¢ Metaphyseal
ā¢ Fallen fragment sign ļ cortical fragment of
pathological # settles in most dependant position
ā¢ Hinged fragment sign ļ fractured fragment
doesnot separate from adjacent cortex
Hinged fragment sign ļ
fractured fragment doesnot
separate from adjacent cortexTONY SCARIA 2010 KMC
200. Simple bone cyst
Mc site ļ proximal humerus 2nd most common site ļ femur
TONY SCARIA 2010 KMC
202. Aneurysmal bone cyst
ā¢ In < 20 yrs of age
ā¢ Mc sites
ā¢ Femur tibia followed by spine (arch of
vertebrae)
ā¢ Eccentric
ā¢ Metaphyseal
ā¢ Expansile
ā¢ Lytic
ā¢ Erosion of overlying cortex
ā¢ On MRI ļ multiple air fluid level
TONY SCARIA 2010 KMC
206. ABC GCT
Age <20 yrs Age 20-40 years (after epiphyseal closure)
Metaphyseal Epiphyseal
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207. Fibrous dysplasia
ā¢ Developmental disorder
most commonly in early
adolescent
ā¢ Mc site are ribs femur
tibia
ā¢ Metaphyseal
ā¢ Radiolucent
ā¢ Sclerotic margins
ā¢ Ground glass appearance
ā¢ Cortical thinning
ā¢ Shepherd crroks deformity
ā¢ Ground glass appearance
ā¢ Shepherd crooks
deformity
TONY SCARIA 2010 KMC
208. Osteochondroma
ā¢ Mc benign tumour
ā¢ Teenagers & young adults
Metaphyseal / diaphyseal
Pedunculated with bony stalk & covered by
cartilaginous cap
Medullary canal is continuous with medullary
canal of normal bone
TONY SCARIA 2010 KMC
209. Osteoid osteoma
ā¢ 5 ā 25 years
ā¢ Diaphysis of long bones ļ femur & tibia
ā¢ Radiolucent nidus &
sclerotic rim
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210. Osteosarcoma
ā¢ Mc primary malignant tumour
ā¢ Metaphysis of long tubular bones
ā¢ Mc site is distal femur followed
proximal tibia
ā¢ Metaphyseal
ā¢ Eccentric
ā¢ Bine formation in matrix
ā¢ Sunray appearance e
ā¢ Codmans triangle
ā¢ Onion peel appearance (mc & characteristic of
ewings sarcoma)
TONY SCARIA 2010 KMC
219. Wormian bones
Bony ossicles with in skull sutures
MC site ļ lambdoid suture
If more than 10 in number & more than 6*4mm in size ļ
abnormal
TONY SCARIA 2010 KMC
220. Os inca
ā¢ Large single wormian bone
ā¢ @ junction of lambdoid & sagittal suture
TONY SCARIA 2010 KMC
221. Wormian bones are also seen in
ā¢ cleidocranial dysplasia,
ā¢ congenital hypothyroidism,
ā¢ pachydermoperiostosis,
ā¢ Menkeās syndrome
ā¢ trisomies.ā
TONY SCARIA 2010 KMC
224. J shaped sella
ā¢ Chronic hydrocephalus
ā¢ Optic glioma, Osteogenesis
imperfecta
ā¢ Neurofibromatosis
ā¢ Mucopolysaccharidosis
ā¢ Achondroplasia
ā¢ Normal varian
d/t resorption of anterior margin of
tuberculum sellae ļ j shaped
TONY SCARIA 2010 KMC
225. Short 4th metacarpal /metatarsal
ā¢ Post traumatic
ā¢ Turners syndorme
ā¢ Pseudohypoparathyroidism
ā¢ Pseudopseudohypoparathyroidism
ā¢ Basal cell nevus syndrome ļ gorlin
syndrome
ā¢ Post infection from sickle cell
anemia
ā¢ Hereditary multiple exostosis
TONY SCARIA 2010 KMC
226. Vertebra plana
ā¢ Vertebra plana is also seen in
ā¢ Eosinophilic granuloma
ā¢ Calves ds (osteochondritis of vertebrae)
ā¢ Ewings sarcoma
ā¢ Metastasis
ā¢ leukemia
TONY SCARIA 2010 KMC
227. Ivory vertebrae
ā¢ Seen in
ā¢ Pagets disease
ā¢ Treated TB
ā¢ Lymphoma
ā¢ Osteoblastic metastasis
TONY SCARIA 2010 KMC
228. Loosers zone
ā¢ these are areas of unmineralized woven bone occurring at sites of
mechanical stress or nutrient vessel entry (pulsations of the arteries)
TONY SCARIA 2010 KMC