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Cardiodrugs

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Tosca Torres
Tosca Torres
Health & Medicine
1 of 136
Cardiovascular Drugs Ma. Tosca Cybil A. Torres, RN, MAN
Learning Objectives ,[object Object],[object Object],[object Object],[object Object]
Antihypertensive
Hypertension ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Goal with hypertension: ,[object Object],[object Object],[object Object],[object Object]
o
Pharmacotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Diuretics ,[object Object],[object Object],[object Object]
Loop Diuretics ,[object Object],[object Object],[object Object]
Loop Diuretics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Loop Diuretics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thiazide ,[object Object],[object Object]
Thiazide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thiazide ,[object Object],[object Object],[object Object]
NCs: Thiazide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Potassium Sparing Diuretics ,[object Object],[object Object],[object Object],[object Object],[object Object]
Potassium Sparing Diuretics cont ,[object Object],[object Object],[object Object],[object Object],[object Object]
NCs: Potassium Sparing Diuretics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Calcium Channel Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object]
Calcium Channel Blockers cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Calcium Channel Blockers cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Calcium Channel Blockers cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]
NCs: Calcium Channel Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
e
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) Angiotensinogen in plasma Juxtaglomerular cells-kidney ↓ Serum Sodium ↓Blood volume Angiotensin I Kidney tubules Angiotensin II Adrenal Cortex ↑ Sodium resorption (H2O resorbed with sodium); ↑ Blood volume RENIN Angiotensin-converting enzyme ALDOSTERONE Intestine, sweat glands, Salivary glands Via vasoconstriction of arterial smooth muscle
Angiotensin Converting Enzyme Inhibitors (ACE-I)- “prils” ,[object Object],[object Object],[object Object]
Angiotensin Converting Enzyme Inhibitors (ACE-I)- “prils” cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
te
NCs: ACE Inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Angiotensin II Receptor Blockers (ARB’s)- “sartans” ,[object Object],[object Object],[object Object],[object Object],[object Object]
Angiotensin II Receptor Blockers (ARB’s)- “sartans” cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Angiotensin II Receptor Blockers (ARB’s)- “sartans” cont ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Beta Blockers- “olols ,[object Object],[object Object],[object Object],[object Object],[object Object]
Beta Blockers- “olols cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Beta Blockers- “olols cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Beta Blockers- “olols cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NCs: Beta-adrenergic Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
y
Alpha 1 -adrenergic Antagonists ,[object Object],[object Object]
NCs: Alpha 1 -adrenergic Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Direct Vasodilators ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NCs: Direct Vasodilators ,[object Object],[object Object],[object Object],[object Object],[object Object]
Direct Vasodilators ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Cardiac Glycosides ,[object Object],[object Object]
Action Potential
Cardiac Glycosides ,[object Object],[object Object],[object Object],[object Object]
Inotropes
Inotropes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class Participation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class Participation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiac Glycosides ,[object Object]
Digoxin MOA
Digoxin (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chronotropes
Chronotropes ,[object Object],[object Object],[object Object]
Chronotropes (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Positive Chronotrope ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Atropine (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Nursing Responsibilities ,[object Object],[object Object],[object Object],[object Object]
Anti-anginal Drugs
Antianginal Drugs ,[object Object],[object Object],[object Object]
Angina Pectoris ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Symptoms of Angina
Nitrites/Nitrates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class Participation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class Participation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug (Trade Name) Common Dosage Onset Duration Amyl nitrate (Vaporole ® ) 0.3 ml inhalation 30-60 sec 10 min ISDN (Isordil ® ) 2.5 - 10 mg SL 5 - 30 mg po qid 2-5 min 2 - 4 hr Nitroglycerin ( Nitro-bid ® ) 2% ointment 15 min 4 - 8 hr ( Nitrostat ® ) 0.3 - 0.6 mg SL 1-3 min 10 - 45 min ( Nitrogard ® ) 1,2,3 mg XR tab 30 min 8 - 12 hr ( Transderm-Nitro ® ) 2.5 - 15 mg/day Transdermal patch 30-60 min 24 hr
MOA ,[object Object],[object Object],[object Object]
Nitroglycerin (NG) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NG (cont’d) ,[object Object],[object Object],[object Object],[object Object]
NG (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antidysrhythmics Antiarrhythmics
What are Arrhythmias? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antidysrhythmics/Antiarrhythmics ,[object Object],[object Object],[object Object]
Antidysrhythmics/Antiarrhythmics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiac Action Potential ,[object Object],[object Object],[object Object],[object Object],[object Object]
Antiarrthymics: Class I ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class I A ,[object Object],[object Object],[object Object]
Class 1A – Quinidine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class 1A – Quinidine (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class I B ,[object Object],[object Object],[object Object],[object Object]
Lidocaine – Class IB ,[object Object],[object Object]
Lidocaine – Class IB (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class I C ,[object Object],[object Object]
Flecainide – Class IC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Flecainide – Class IC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class II – Beta Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Propranolol Warning ,[object Object],[object Object],[object Object],[object Object]
Class III ,[object Object],[object Object],[object Object],[object Object],[object Object]
Amiodarone – Class III ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Amiodarone – Class III (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Class IV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Sympathomimetics
Sympathomimetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epinephrine ,[object Object],[object Object],[object Object],[object Object],[object Object]
Epinephrine MOA
Epinephrine (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epinephrine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vasopressors
Vasopressors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vasoconstrictor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vasopressin ,[object Object],[object Object],[object Object],[object Object]
Vasopressin (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vasopressin (cont’d) ,[object Object],[object Object],[object Object],[object Object]
Vasopressin (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anticoagulants
Antiplatelets/Anticoagulants ,[object Object],[object Object],[object Object]
Types of Antiplatelets/Anticoagulants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antiplatelets/Anticoagulants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Coagulation Cascade
Warfarin – Oral Anticoagulant ,[object Object]
Warfarin (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Warfarin Warnings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Warfarin (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
Fibrinolytic Enzymes
Fibrinolytic Enzymes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Streptokinase (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Streptokinase (cont’d) ,[object Object],[object Object],[object Object],[object Object]
Streptokinase (cont’d)
Antilipidemics
Antilipidemics ,[object Object]
Types of antilipidemics ,[object Object],[object Object],[object Object],[object Object]
Side effects ,[object Object],[object Object],[object Object],[object Object]
Nursing responsibilities ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]

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