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Nsaids
- 1. DR.UMA KADAM M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC
- 13. COX Enzyme:Prostaglandin Effects vasodilation Kidney aggregation Platelets protect mucosa Stomach Modulate pain perception Promote fever (hypothalamus) Brain Inflammation Peripheral injury site COX-2: harmful COX-1: beneficial
- 14. Effects of COX Inhibition by Most NSAIDS NSAIDs : anti-platelet—decreases ability of blood to clot COX-1 Gastric ulcers Bleeding Acute renal failure COX-2 Reduce inflammation Reduce pain Reduce fever
- 25. ASPIRIN (NSAIDs) INTERACTIONS: / Diuretics diuretic response& Probencid / NSAIDs inhibit tubular Antagonize uricosuric effect methotrexate uric acid secretion