MMPs Overview By Vijay Avin BR

1. Matrix metalloproteinases
(MMPs) & Role in Angiogenesis
Vijay Avin BR, Molecular Biomedicine Laboratory, Sahyadri Sceince College,
Shimoga, Karnataka, India

2. • A protease (also termed peptidase or proteinase) is any enzyme that
performs proteolysis, that is, begins protein catabolism by hydrolysis of
the peptide bonds that link amino acids together in the polypeptide chain forming
the protein.
Catalytic residue
– Serine proteases
– Threonine proteases
– Cysteine proteases
– Aspartate proteases
– Glutamic acid proteases
– Metalloproteases - using a metal, usually zinc

3. • Matrix metalloproteinases (MMPs) are a large family
of calcium-dependent zinc-containing
endopeptidases.
• which are responsible for the tissue remodeling and
degradation of the extracellular matrix (ECM),
including collagens, elastins, gelatin, matrix
glycoproteins, and proteoglycan.
• Matrix metalloproteinases are excreted by a variety
of connective tissue and pro-inflammatory cells
including fibroblasts, osteoblasts, endothelial cells,
macrophages, neutrophils, and lymphocytes.

7. Transduction of MMPs

8. Involvement of MMPs in physiological and pathological
processes

9. Activation of MMPs leads to........

10. MMps in Pathological condition....

11. MMPs and cancer

12. Angiogenesis and MMPs

13. Angiogenesis and MMPs Contd.....

14. Wat happnes with in the blood
vessels?? MMPs in blood vessels