SlideShare a Scribd company logo
1 of 40
Interventional Pain Management Spinal anatomy and Intrathecal Drug Delivery Amitabh Gulati MSKCC Dept. of Anesthesiology and Critical Care
Objectives ,[object Object],[object Object],[object Object]
 
The Spine
The Spinal Cord
Cord anatomy
Cord anatomy
The Rexed lamina ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Ascending Spinosensory tracts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Descending inhibition ,[object Object],[object Object],[object Object],[object Object],[object Object]
Brachial plexus
Lumbar plexus
Sacral Plexus
The Autonomic Nervous System
Visceral innervation
 
Intraspinal techniques Permanent Epidural, DuPen Intratehcal implantable pump
Opiate receptor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Opiate effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epidural administration ,[object Object],[object Object],[object Object],[object Object],Bernards et al. Anesthesiology 2003 Epidural Spread Intrathecal spread
Epidural Opiates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bernards et al. Anesthesiology 2003
Spinal opiates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Distribution of morphine ,[object Object],[object Object],[object Object],[object Object],[object Object],Flack et al. A&A 2011
Intrathecal opioids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Intrathecal bupivacaine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clonidine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ziconotide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Baclofen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Consensus maximum doses
Consensus algorithm
The Controversy of Trialing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dose Conversions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epidural trial ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The CSE trial ,[object Object],[object Object]
Tips to convert to IT pump ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
An example ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Continued ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Questions

More Related Content

What's hot

19 Insulin Types
19 Insulin Types19 Insulin Types
19 Insulin Types
kdiwavvou
 

What's hot (20)

Madison Fire Protocols Program
Madison Fire Protocols ProgramMadison Fire Protocols Program
Madison Fire Protocols Program
 
Mycophenolate Mofetil in Primary Glomerulonephritis
Mycophenolate Mofetil in Primary GlomerulonephritisMycophenolate Mofetil in Primary Glomerulonephritis
Mycophenolate Mofetil in Primary Glomerulonephritis
 
Protocol of-rpgn2014 (1)
Protocol of-rpgn2014 (1)Protocol of-rpgn2014 (1)
Protocol of-rpgn2014 (1)
 
TB MENINGITIS and anti tuberculous drugs
TB MENINGITIS and anti tuberculous drugsTB MENINGITIS and anti tuberculous drugs
TB MENINGITIS and anti tuberculous drugs
 
Aminoglycoside Pharmacokinetics/Pharmacodynamics
Aminoglycoside Pharmacokinetics/PharmacodynamicsAminoglycoside Pharmacokinetics/Pharmacodynamics
Aminoglycoside Pharmacokinetics/Pharmacodynamics
 
CASE ON BENZODIAZEPINE POISONING
CASE ON BENZODIAZEPINE POISONINGCASE ON BENZODIAZEPINE POISONING
CASE ON BENZODIAZEPINE POISONING
 
Intravenous mg so4 in asthma
Intravenous mg so4 in asthmaIntravenous mg so4 in asthma
Intravenous mg so4 in asthma
 
Trasturel 150mg injection
Trasturel 150mg injectionTrasturel 150mg injection
Trasturel 150mg injection
 
Poisoning management
Poisoning managementPoisoning management
Poisoning management
 
Glucocorticoids in rheumatological diseases
Glucocorticoids in rheumatological diseasesGlucocorticoids in rheumatological diseases
Glucocorticoids in rheumatological diseases
 
Insulin therapy and glucose monitoring
Insulin therapy and glucose monitoringInsulin therapy and glucose monitoring
Insulin therapy and glucose monitoring
 
Insulin therapy: art of initiation and titration
Insulin therapy: art of initiation and titration Insulin therapy: art of initiation and titration
Insulin therapy: art of initiation and titration
 
Neuroleptic malignant syndrome
Neuroleptic malignant syndromeNeuroleptic malignant syndrome
Neuroleptic malignant syndrome
 
Cd009395
Cd009395Cd009395
Cd009395
 
Gabapentin
GabapentinGabapentin
Gabapentin
 
insulin THERAPY
 insulin THERAPY insulin THERAPY
insulin THERAPY
 
19 Insulin Types
19 Insulin Types19 Insulin Types
19 Insulin Types
 
Magnesium sulfate
Magnesium sulfateMagnesium sulfate
Magnesium sulfate
 
Managing Diabetes With Insulin by Dr Shahjada Selim
Managing DiabetesWith Insulin by Dr Shahjada SelimManaging DiabetesWith Insulin by Dr Shahjada Selim
Managing Diabetes With Insulin by Dr Shahjada Selim
 
Metoclopramide for nausea and vomiting prophylaxis during and
Metoclopramide for nausea and vomiting prophylaxis during andMetoclopramide for nausea and vomiting prophylaxis during and
Metoclopramide for nausea and vomiting prophylaxis during and
 

Similar to Spinal anatomy and_intrathecal_drugs

Medical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitationMedical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitation
webzforu
 
Medical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitationMedical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitation
webzforu
 
Pain management overview 2013
Pain management overview 2013Pain management overview 2013
Pain management overview 2013
derosaMSKCC
 
Pharmcotherapy of helmintic infections
Pharmcotherapy of helmintic infectionsPharmcotherapy of helmintic infections
Pharmcotherapy of helmintic infections
Karthiga M
 

Similar to Spinal anatomy and_intrathecal_drugs (20)

Salon a 14 kasim 14.45 16.00 sai̇t karakurt-ing
Salon a 14 kasim 14.45 16.00 sai̇t karakurt-ingSalon a 14 kasim 14.45 16.00 sai̇t karakurt-ing
Salon a 14 kasim 14.45 16.00 sai̇t karakurt-ing
 
Opioid pain surgery2010
Opioid pain surgery2010Opioid pain surgery2010
Opioid pain surgery2010
 
Medical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitationMedical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitation
 
Medical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitationMedical management of vestibular disorders and vestibular rehabilitation
Medical management of vestibular disorders and vestibular rehabilitation
 
Pain in the ICU
Pain in the ICUPain in the ICU
Pain in the ICU
 
Intravenous anaesthetic agents
Intravenous anaesthetic agentsIntravenous anaesthetic agents
Intravenous anaesthetic agents
 
Status epilapticus
Status epilapticusStatus epilapticus
Status epilapticus
 
Status epilapticus
Status epilapticusStatus epilapticus
Status epilapticus
 
Eclampsia
EclampsiaEclampsia
Eclampsia
 
Motot neuron disease
Motot neuron diseaseMotot neuron disease
Motot neuron disease
 
Interventional Techniques For Cancer Pain Management.
Interventional Techniques For Cancer Pain Management.Interventional Techniques For Cancer Pain Management.
Interventional Techniques For Cancer Pain Management.
 
Pain management overview 2013
Pain management overview 2013Pain management overview 2013
Pain management overview 2013
 
5 regional anesthesia
5 regional anesthesia5 regional anesthesia
5 regional anesthesia
 
GP Palliative Care Update 2019 Neuropathic Pain Dr. Paul McNamara with thanks...
GP Palliative Care Update 2019 Neuropathic Pain Dr. Paul McNamara with thanks...GP Palliative Care Update 2019 Neuropathic Pain Dr. Paul McNamara with thanks...
GP Palliative Care Update 2019 Neuropathic Pain Dr. Paul McNamara with thanks...
 
management of SLE.pptx
management of SLE.pptxmanagement of SLE.pptx
management of SLE.pptx
 
Intrathecal baclofen
Intrathecal baclofenIntrathecal baclofen
Intrathecal baclofen
 
Iv induction agents
Iv induction agentsIv induction agents
Iv induction agents
 
Perioperative pain management
Perioperative pain managementPerioperative pain management
Perioperative pain management
 
SEDATION IN PAEDIATRIC POPULATION PPT.pptx
SEDATION IN PAEDIATRIC POPULATION PPT.pptxSEDATION IN PAEDIATRIC POPULATION PPT.pptx
SEDATION IN PAEDIATRIC POPULATION PPT.pptx
 
Pharmcotherapy of helmintic infections
Pharmcotherapy of helmintic infectionsPharmcotherapy of helmintic infections
Pharmcotherapy of helmintic infections
 

Recently uploaded

Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
mahaiklolahd
 

Recently uploaded (20)

Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
 
Top Rated Hyderabad Call Girls Erragadda ⟟ 9332606886 ⟟ Call Me For Genuine ...
Top Rated  Hyderabad Call Girls Erragadda ⟟ 9332606886 ⟟ Call Me For Genuine ...Top Rated  Hyderabad Call Girls Erragadda ⟟ 9332606886 ⟟ Call Me For Genuine ...
Top Rated Hyderabad Call Girls Erragadda ⟟ 9332606886 ⟟ Call Me For Genuine ...
 
Call Girls Guntur Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Guntur  Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Guntur  Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Guntur Just Call 8250077686 Top Class Call Girl Service Available
 
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
 
(Low Rate RASHMI ) Rate Of Call Girls Jaipur ❣ 8445551418 ❣ Elite Models & Ce...
(Low Rate RASHMI ) Rate Of Call Girls Jaipur ❣ 8445551418 ❣ Elite Models & Ce...(Low Rate RASHMI ) Rate Of Call Girls Jaipur ❣ 8445551418 ❣ Elite Models & Ce...
(Low Rate RASHMI ) Rate Of Call Girls Jaipur ❣ 8445551418 ❣ Elite Models & Ce...
 
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
 
Model Call Girls In Chennai WhatsApp Booking 7427069034 call girl service 24 ...
Model Call Girls In Chennai WhatsApp Booking 7427069034 call girl service 24 ...Model Call Girls In Chennai WhatsApp Booking 7427069034 call girl service 24 ...
Model Call Girls In Chennai WhatsApp Booking 7427069034 call girl service 24 ...
 
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
 
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
 
Top Rated Bangalore Call Girls Majestic ⟟ 9332606886 ⟟ Call Me For Genuine S...
Top Rated Bangalore Call Girls Majestic ⟟  9332606886 ⟟ Call Me For Genuine S...Top Rated Bangalore Call Girls Majestic ⟟  9332606886 ⟟ Call Me For Genuine S...
Top Rated Bangalore Call Girls Majestic ⟟ 9332606886 ⟟ Call Me For Genuine S...
 
Call Girls Vasai Virar Just Call 9630942363 Top Class Call Girl Service Avail...
Call Girls Vasai Virar Just Call 9630942363 Top Class Call Girl Service Avail...Call Girls Vasai Virar Just Call 9630942363 Top Class Call Girl Service Avail...
Call Girls Vasai Virar Just Call 9630942363 Top Class Call Girl Service Avail...
 
O898O367676 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
O898O367676 Call Girls In Ahmedabad Escort Service Available 24×7 In AhmedabadO898O367676 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
O898O367676 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
 
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
 
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
 
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
 
Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...
Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...
Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...
 
Call Girls Vadodara Just Call 8617370543 Top Class Call Girl Service Available
Call Girls Vadodara Just Call 8617370543 Top Class Call Girl Service AvailableCall Girls Vadodara Just Call 8617370543 Top Class Call Girl Service Available
Call Girls Vadodara Just Call 8617370543 Top Class Call Girl Service Available
 
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
 
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
 
Manyata Tech Park ( Call Girls ) Bangalore ✔ 6297143586 ✔ Hot Model With Sexy...
Manyata Tech Park ( Call Girls ) Bangalore ✔ 6297143586 ✔ Hot Model With Sexy...Manyata Tech Park ( Call Girls ) Bangalore ✔ 6297143586 ✔ Hot Model With Sexy...
Manyata Tech Park ( Call Girls ) Bangalore ✔ 6297143586 ✔ Hot Model With Sexy...
 

Spinal anatomy and_intrathecal_drugs