Pathology of Congenital WBC disorders.

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Shashidhar Venkatesh Murthy
A/Prof & Head of Pathology
College of Medicine & Dentistry
Congenital WBC Disorders

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Congenital WBC disorders:
 Leucocytosis:
 Idiopathic Neutrophilia. Increased neutrophils. Asymptomatic.
 Leucopenia:
 Ethnic or Benign familial Neutropenia. (Jews, Blacks & Arab)
 Cyclical Neutropenia. – cyclical variation in WBC counts.
 Kostmann’s syndrome: Congenital agranulocytosis – lack of G-CSF
severe neutropenia & severe infections.
 Felty’s syndrome: Rheumatoid arthritis & severe neutropenia.
 Severe Combined Immunodeficiency: absent T Lymphocytes.
 WBC Function disorders:
 Chronic Granulomatous Disease:
Defective microbicidal function.
 Lazy leukocyte syndrome.

3. “Everyone is a genius. But if you
judge a fish by its ability to climb a
tree, it will spend its whole life
believing it is stupid…!”
- Albert Einstein