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Pathology of Thyroid & Endocrine Disorders
1. Challenge….! Jan 2009: 4 th Year Students at JCU School of Medicine set new record.…!!! 100% Pass & Class Average of over 70% 99% Pass & Class Average of 68% Highest Are you ready for the Challenge….? Yes We Can…!
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5. Oprah has battled with her weight for years. Recently she was diagnosed with hyperthyroidism . which sped up her metabolism and prevented sleep. Oprah eventually "blew out" her thyroid and experienced classic symptoms of hypothyroidism : Her metabolism slowed and she felt sluggish and tired. Hyper - - Hypo
6. Sir William Osler, M.D. said… As is our pathology so is our practice... what the pathologist thinks today, the physician does tomorrow. Pathology, The science of Medicine
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8. Pathology Lab resources: Muse um Specimens GN-01 Pheochromocytoma GN-02 Adenoma (Hurthle Cell) GR-01 Adrenal Haemorrhage GR-02 Nodular Thyroid GR-03 Nodular Hyperplasia (MNG) GR-04 Benign Nodular Thyroid (MNG) GR-05 Thyroid Cyst Digital Slides Thyroid Graves (JCU slide) Endo-39-Thyroid MNG Endo-40-Adrenal adenoma Endo-46-Pheochromocytoma Endo-47-Hashimoto-Pap ca Endo-51-Hashimotos thyroiditis Endo-52-Hashimotos thyroiditis Endo-53-Graves Endo-54-Hashimotos thyroiditis Endo-57-Pitutary Normal Endo-58-Thyroid Normal Endo-59-Adrenal Normal
11. 8. A PLEASING PERSONALITY WITH PMA Assembling an attractive personality is a must. Your personality is your greatest asset or your greatest liability, for it embraces everything that you control: mind, body, soul and spirit. Learn to be pleasant even when others are being unpleasant to you. Positive Mental Attitude: 17 Success Principles… Some bring happiness where ever they go, & some whenever….!
12. Pathology of Thyroid Disorders Dr. Venkatesh M. Shashidhar Associate Prof. & Head of Pathology
41. 3. GOING THE EXTRA MILE Very simply, this principle means: Render or give more and better service than you are paid for, and sooner or later you will receive compound interest from your investment of going the extra mile. Positive Mental Attitude: 17 Success Principles…
55. 14. CREATIVE VISION Creative vision requires you to stimulate your imagination to work towards your goal, your target and your major purpose, and to put the result of that imagination to work. Positive Mental Attitude: 17 Success Principles…
62. Nontoxic-Multi Nodular Goitre. A: conspicuous neck mass. B: Coronal section showing numerous irregular nodules, some with hemorrhage. C: Microscopy: variation in the size of the follicles. Note: TSH, T3,T4 Normal (Euthyroid)
64. 5. SELF DISCIPLINE Self discipline is doing what you are supposed to be doing for the moment. It is employing the "DO IT NOW“ philosophy Positive Mental Attitude: 17 Success Principles…
69. Carcinoma of Thyroid Type (%) age spread Prognosis Papillary 60-70 young adults 20-40 (<45y) Lymphatic , to local nodes Excellent Follicular 20-25 Young-middle 40-50 (>45) Blood stream, especially to bone Good with radio-iodine therapy. Anaplastic 10-15 Elderly Aggressive local extension Very poor Medullary (C-cells) 5-10 Usually elderly, but familial cases occur Local, lymphatic, blood stream Variable. More aggressive in familial cases
85. 11. CONTROLLED ATTENTION WITH PMA Controlled attention is organised mind power. It is the highest form of self discipline. Keep your mind on the things you want and off the things you don't want. Positive Mental Attitude: 17 Success Principles…
86. Challenge….! Jan 2009: 4 th Year Students at JCU School of Medicine set new record.…!!! 100% Pass & Class Average of over 70% 99% Pass & Class Average of 68% Highest Are you ready for the Challenge….? Yes We Can…!
87. Pathology of Endocrine System Overview Dr. Shashidhar V. Murthy Senior Lecturer & Head of Pathology James Cook University School of Medicine
104. “ One's philosophy is not best expressed in words; it's expressed in the choices one makes. Eleanor Roosevelt1884-1962, U.S. diplomat, author, and political figure. Wife of Franklin D. Roosevelt
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106. Test Normal Interpretation "TSH" Test -- Thyroid Stimulating Hormone / Serum thyrotropin 0.3 to 6 Under .4 can indicate possible hyperthyroidism. Over 6 is considered indicative of hypothyroidism. Total T4 / Serum thyroxine 4.5 to 12.5 Less than 4.5 can be indicative of an underfunctioning thyroid when TSH is also elevated. Over 12.5 can indicate hyperthyroidism. Low T4 with low TSH can sometimes indicate a pituitary problem. Free T4 / Free Thyroxine - FT4 0.7 to 2.0 Less than 0.7 is considered indicative of possible hypothyroidism. T3 / Serum triiodothyronine 80 to 220 Less than 80 can indicate hypothyroidism.
108. Pemberton’s Sign Within 30 seconds after raising both arms (Pemberton’s maneuver), marked facial plethora develops (Pemberton’s sign) indicating compression of the jugular veins (Panel B) – commonly due to enlarged thyroid. From: NEJM-Images in clinical medicine ( http://content.nejm.org/cgi/reprint/350/13/1338.pdf )