UTI

1. Pain nourishes courage. You
can't be brave if you've only
had wonderful things happen
to you.
– Mary Tyler Moore

2. CLINICAL PATHOLOGY
The foundation of clinical medicine.
Shashidhar Venkatesh Murthy
A/Prof & Head of Pathology
College of Medicine & Dentistry
BPH2: Urinary Tract Dis: UTI
CPC : Term4 Week3 - BPH 2/6
System : Urinary Tract.
Topic : 1: Overview 2: UTI 3: BPH 4: Tumours 5: Obstructions Lithiasis 6: Others 7: GLS

3. 3
UTI: Overview
 Urethritis, Cystitis, Prostatitis, Pyelonephritis
 90% by Escherichia coli *, Recurrence (40%),
 Uropathogenic strains (UPEC). P fimbriae or pili
– bind to urothelium.
 Colonize colon spread to urinary tract.
 Staph. Saprophyticus, Proteus, Klebs., Entero.,
Ureaplasma.. - Rare
Clinical:
 Females*, Anatomy*, sexual, UT abnormality /
Obstructions.
 Dysuria, Low grade fever, frequency, urgency,
 Flank pain, high fever, – pyelonephritis.
 Complications: E coli septicemia* endotoxins
 DIC*, Prostatitis, Prostatic abscess.

4. A friend is someone with
whom you dare to be
yourself.
– Frank Crane

5. 5
UTI: Diagnosis: E coli
 Blood: Leukocytosis – neutrophilia
 Midstream clean catch Urine specimen*
 Dipstick: Leukocyte esterase & nitritie +ve.
 Urine: pyuria, neutrophils, bacteria,
Microscopy gram stain:
 Gram negative Bacilli, Lactose fermenting.
 Also Entero.. & Klebsiella ferment lactose.
 Further tests to confirm: E coli  urease –ve
(unlike Klebsiella & Proteus +ve)
 MacConkey agar* selective, indicator media.
 24h, 37°C, Aerobic, Pink colony
(lactose ferment  acid  pH indicator),
 Beta-hemolytic on blood agar.

6. A friend is someone with
whom you dare to be yourself.
– Frank Crane